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- W2356554859 abstract "Objective To establish the time course of chronic cerebral vasospam in rat with digital subtract angiograghy(DSA). Methods Fifty six rats were arranged to seven groups according to designated time intervals since first cisterna magna injection.Chronic vasospasm was induced in male Sprague Dawley rats by an injection of autologuous blood (250 microl) into the cisterna magna followed by a second injection 24 hours later.A contral group of eight animals were treated with injections of 0.9% sodium chloride solution.At the designated time,pressure controlled digital subtract angiography after retrograde cannulation of the exernal carotid artery was performanced.The animals were perfusion fixed and their middle cerebral arteries (MCA) were removed to assess their diameter with the aid of a microscope. Results In the angiogram of digital subtract angiography, chronic cerebral vasospasm appeared at the second day after the first cisterna magna injection and reached the peak in the eighth day.The peak of vasospasm continued until the twelfth day.The vasospasm of MCA released in some extension at the fourteenth day.The alteration of MCA diameter in optial microscop was similar to that of angiogram according with the time cours of cerebral vasospasm except for the twelfth day's. Conclusion The time course of chronic cerebral vasospasm in angiogram of digital substract angiography can provide reliable and complete information about the alteration of cerebral artery in rats for the delayed cerebral vasospasm reseach." @default.
- W2356554859 created "2016-06-24" @default.
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- W2356554859 date "2002-01-01" @default.
- W2356554859 modified "2023-09-25" @default.
- W2356554859 title "Time Course of Chronic Cerebral Vasospasm in Rat by DSA" @default.
- W2356554859 hasPublicationYear "2002" @default.
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