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- W2356555094 abstract "Objective:To investigate the mutation of nm23-H1 gene and to explore the relationship between nm23-H1 mutation and the development,progression and metastasis of human hepatocellular carcinoma(HCC).Methods: Mutations of the exon1,2,4 of nm23-H1 gene in 16 HCC tissues,12 adjacent liver tissues and 4 normal liver tissues were examined by means of PCR-SSCP.Results:Altogether there were 5 cases of nm23-H1 gene mutation.One of exon 2 homozygous loss of allele of nm23-H1 gene was examined in adjacent liver tissue.The nm23-H1 gene mutation was also examined that one of exon1 in HCC tissues,one of exon2 in adjacent liver tissue and two of exon2 in adjacent liver tissue.Conclusion: The mutation of nm23-H1 gene is rare in HCC.It is showed that nm23-H1 gene mutation maybe associated with the progression and metastasis of HCC." @default.
- W2356555094 created "2016-06-24" @default.
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- W2356555094 date "2007-01-01" @default.
- W2356555094 modified "2023-09-24" @default.
- W2356555094 title "PCR-SSCP analysis of nm23-H1 gene mutation in human hepatocellular carcinoma." @default.
- W2356555094 hasPublicationYear "2007" @default.
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