Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356556145> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2356556145 abstract "Objective To investigate the effect of hypertonic conditions induces mucin(MUC)5AC secretion by HBE16 cell and the potential mechanism of PKC-HSP70 pathways.Methods HBE16 cells were cultured in hypertonic medium to induce mucus hypersecretion in vitro.Inhibitors of PKC isoforms were used to interference HBE16 cells.HSP70-2 cells were determined by Western blot.RT-PCR was used to detecte the transcriptional level of HSP70-2.Mucin(MUC)5AC protein content in supernatant was analysed by ELISA.Results The levels of HSP70-2,HSP70-2 mRNA and MUC5AC proteins werer strongly increased after cells were exposed to hypertonic conditions,and the expression content was increased in a time-dependent manner(all P0.05).The expression in G6976 group was significantly lower than that in hypertonic group(P0.01) and was still higher than that in control(P0.05).Treatment with Safingol,LY333531 and Rottlerin exerted no effects on hypertonicity-induced content of HSP70-2,HSP70-2 mRNA and MUC5AC proteins.Conclusion Hypertonic medium induces the MUC5ACmucin hypersecretion by human bronchial epithelial cells.HSP70-2 mediated hypertonic stress induces mucin hypersecretion through a PKCμ dependent signaling pathways." @default.
- W2356556145 created "2016-06-24" @default.
- W2356556145 creator A5048354020 @default.
- W2356556145 creator A5085205118 @default.
- W2356556145 date "2011-01-01" @default.
- W2356556145 modified "2023-09-25" @default.
- W2356556145 title "Hypertonicity induces mucus hypersecretion by human airway epithelial cells" @default.
- W2356556145 hasPublicationYear "2011" @default.
- W2356556145 type Work @default.
- W2356556145 sameAs 2356556145 @default.
- W2356556145 citedByCount "0" @default.
- W2356556145 crossrefType "journal-article" @default.
- W2356556145 hasAuthorship W2356556145A5048354020 @default.
- W2356556145 hasAuthorship W2356556145A5085205118 @default.
- W2356556145 hasConcept C104317684 @default.
- W2356556145 hasConcept C117277713 @default.
- W2356556145 hasConcept C11960822 @default.
- W2356556145 hasConcept C134018914 @default.
- W2356556145 hasConcept C153911025 @default.
- W2356556145 hasConcept C179264091 @default.
- W2356556145 hasConcept C185592680 @default.
- W2356556145 hasConcept C18903297 @default.
- W2356556145 hasConcept C195794163 @default.
- W2356556145 hasConcept C202751555 @default.
- W2356556145 hasConcept C2776415932 @default.
- W2356556145 hasConcept C2777312293 @default.
- W2356556145 hasConcept C2778769476 @default.
- W2356556145 hasConcept C49039625 @default.
- W2356556145 hasConcept C54355233 @default.
- W2356556145 hasConcept C55493867 @default.
- W2356556145 hasConcept C81885089 @default.
- W2356556145 hasConcept C86803240 @default.
- W2356556145 hasConcept C95444343 @default.
- W2356556145 hasConceptScore W2356556145C104317684 @default.
- W2356556145 hasConceptScore W2356556145C117277713 @default.
- W2356556145 hasConceptScore W2356556145C11960822 @default.
- W2356556145 hasConceptScore W2356556145C134018914 @default.
- W2356556145 hasConceptScore W2356556145C153911025 @default.
- W2356556145 hasConceptScore W2356556145C179264091 @default.
- W2356556145 hasConceptScore W2356556145C185592680 @default.
- W2356556145 hasConceptScore W2356556145C18903297 @default.
- W2356556145 hasConceptScore W2356556145C195794163 @default.
- W2356556145 hasConceptScore W2356556145C202751555 @default.
- W2356556145 hasConceptScore W2356556145C2776415932 @default.
- W2356556145 hasConceptScore W2356556145C2777312293 @default.
- W2356556145 hasConceptScore W2356556145C2778769476 @default.
- W2356556145 hasConceptScore W2356556145C49039625 @default.
- W2356556145 hasConceptScore W2356556145C54355233 @default.
- W2356556145 hasConceptScore W2356556145C55493867 @default.
- W2356556145 hasConceptScore W2356556145C81885089 @default.
- W2356556145 hasConceptScore W2356556145C86803240 @default.
- W2356556145 hasConceptScore W2356556145C95444343 @default.
- W2356556145 hasLocation W23565561451 @default.
- W2356556145 hasOpenAccess W2356556145 @default.
- W2356556145 hasPrimaryLocation W23565561451 @default.
- W2356556145 hasRelatedWork W1502678335 @default.
- W2356556145 hasRelatedWork W1863641532 @default.
- W2356556145 hasRelatedWork W1974494462 @default.
- W2356556145 hasRelatedWork W1981391846 @default.
- W2356556145 hasRelatedWork W2040252238 @default.
- W2356556145 hasRelatedWork W2051144867 @default.
- W2356556145 hasRelatedWork W2065771658 @default.
- W2356556145 hasRelatedWork W2081316178 @default.
- W2356556145 hasRelatedWork W2081934986 @default.
- W2356556145 hasRelatedWork W2151088077 @default.
- W2356556145 hasRelatedWork W2166587305 @default.
- W2356556145 hasRelatedWork W2171528197 @default.
- W2356556145 hasRelatedWork W2371747069 @default.
- W2356556145 hasRelatedWork W2416238758 @default.
- W2356556145 hasRelatedWork W2757374123 @default.
- W2356556145 hasRelatedWork W2767345698 @default.
- W2356556145 hasRelatedWork W2982716214 @default.
- W2356556145 hasRelatedWork W2990825226 @default.
- W2356556145 hasRelatedWork W3043293846 @default.
- W2356556145 hasRelatedWork W3080885521 @default.
- W2356556145 isParatext "false" @default.
- W2356556145 isRetracted "false" @default.
- W2356556145 magId "2356556145" @default.
- W2356556145 workType "article" @default.