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- W2356556891 abstract "Objective To study the inhibitory effects of Lifein on growth of bladder tumor and the underlying mechanisms. Method EJ cells were treated with Lifein at different concentrations.MTT cell proliferation assay was used to observe the inhibitory effect.The cell cycle and cell apoptosis were detected by FCM.In the in vivo experiment,16 Balb/ c nude mice of 4-6 weeks-old were used to build bladder cancer model,which were randomized into Lifein group(6mg/ kg) and control group(saline).Cytokines(IL-2,TNF-α) were detected by ELISA.Immunocytochemical staining was used to analyze the expression of p53,and IL-12 protein.Result Lifein inhibited the proliferation of EJ cells by dosedependent and time-dependent manner.EJ cells were treated with 100μg/ml Lifein for 24 and 48 hours,cells in G_2/M phase were increased in cell cycle,but S-phase cells decreased.In the in vivo experiment,the level of IL-2 and TNF-αincreased in Lifein group.Results of immunocytochemical staining showed that Lifein down-regulated the expression of p53 protein,while up-regulated the IL-12 expression.Conclusion Lifein can change the distribution of cell cycle,inhibit the proliferation of bladder cancer EJ cell,increase the level of IL-2,TNF-αand IL-12,decrease the expression of p53 protein.Thus,it can inhibit and even kill bladder cancer cells." @default.
- W2356556891 created "2016-06-24" @default.
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- W2356556891 date "2013-01-01" @default.
- W2356556891 modified "2023-09-23" @default.
- W2356556891 title "Experimental study on the inhibitory effect of Lifein on growth of bladder tumor" @default.
- W2356556891 hasPublicationYear "2013" @default.
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