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- W2356557834 abstract "AIM:To investigate the effects of drynaria total flavonoids on serum levels of leptin(LEP),interleukin 6(IL-6),prostaglandin E_2(PGE_2)and the expression of boneβ_2-adrenergic receptor(ADRB2)in a rat model of ovariectomized osteoporosis(OP).METHODS:The osteoporosis model was established by ovariectomy.Twelve weeks after modeling,bone mineral density(BMD)was determined by dual-energy X-ray absorptiometry to verify successful modeling.Enzyme-linked immunosorbent assay was applied to detect the concentrations of LEP,IL-6 and PGE_2 in serum. The expression of ADRB2 was determined by immunohistochemical technique.RESULTS:Compared with sham group,BMD of the rats in model group significantly decreased in multiple regions 12 weeks after modeling(P0.01).The serum levels of LEP,IL-6 and PGE_2 in model group were significantly higher than those in sham group(P0.05).The levels of LEP,IL-6 and PGE_2 in drynaria total flavonoids group were significandy lower than those in model group(P0.01).No significant difference of PGE_2 between these 2 groups was observed.The ADRB2 expression in sham group and treatment group was significantly different from that in model group,and no significant difference between sham group and treatment group was found.CONCLUSION:The serum levels of LEP,IL-6 and PGE_2 and the expression of bone ADRB2 increased in OP rats.Drynaria total flavonoids reduce the production of LEP,IL-6 and the expression of ADRB2, and suppress the bone absorption,which may be one of the mechanisms in treating OP." @default.
- W2356557834 created "2016-06-24" @default.
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- W2356557834 date "2011-01-01" @default.
- W2356557834 modified "2023-09-25" @default.
- W2356557834 title "Effects of drynaria total flavonoids on serum levels of leptin,interleukin 6,prostaglandin E_2 and expression of boneβ_2-adrenergic receptor in ovariectomized osteoporosis rats" @default.
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