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- W2356558875 abstract "Aim To study the effect and mechanism of aldosterone on experimental rat liver fibrosis.Methods Eighty male Wistar rats were randomly divided into three groups:normal control group(A group,16 rats),liver fibrosis model group I (B group,54 rats) and aldosterone group I (C group,10 rats).The rats of group B and C were intraperitoneally injected with CCl 4 to induce liver fibrosis.C group rats were administrated aldosterone from 1st week.All of the C group rats were killed after 6 weeks,8 rats of A group and 8 rats of B group selected randomly were killed in the meantime.The survival rats of B group were randomly divided into two groups:liver fibrosis model groupⅡ(D group,12) and aldosterone groupⅡ(E group,10) which were administrated aldosterone from 7th week.All the rats were killed after 10 weeks.Liver function and serum HA,LN,CIV, PCIII were tested,the expression of TIMP-1 were determined by immunohistochemical staining and analyzed by computer.Results In comparison with group B,the serum level of ALT,AST,HA,LN,CIV, PCIll of group C rats were markedly reduced( P 0.01),the activity of TIMP-1 markedly reduced(0.34±0.05 vs 0.45±0.05, P 0.01).The activity of TIMP-I of group E also markedly reduced in comparison with group D (0.31±0.07 vs 0.42±0.06, P 0.01).Conclusion Aldosterone has obvious effect on liver fibrosis,it might improve the degradation of liver extracellular matrix through inhibiting the activity of TIMP-1." @default.
- W2356558875 created "2016-06-24" @default.
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- W2356558875 date "2003-01-01" @default.
- W2356558875 modified "2023-09-26" @default.
- W2356558875 title "Experimental investigation of the effect of aldosterone on liver fibrosis" @default.
- W2356558875 hasPublicationYear "2003" @default.
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