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- W2356561710 abstract "Objective To investigate the relationship between fibroblast proliferation promoted by high density iodine and basic fibroblast growth factor(bFGF) as well as fibroblast growth factor receptor type2(FGFR2), and to explore the mechanism of high density iodine in causing the formation of membrane in Budd-Chiari syndrome(BCS). Methods ① The fibroblasts, which were cultured in high density of iodine in vitro, were divided into 5 groups: control group, solvent group, KI group, FGFR inhibitor group and combination group(FGFR inhibitor together with KI). The proliferation rate of fibroblasts of each group was determined by CCK-8 assay. ② The FGFR2 protein expression level of bFGF and FGFR cultured in different concentrations of iodine(0, 250, 500, 1 000, 2 000 and 3 000 ug/L) was determined by Western-blot method. Quantitative data difference between groups was analyzed by one-way ANOVA method. LSD method was used to compare the experimental group with control group. Statistical significant was given in P values,the difference was considered to be statistically significant when P 0.05. Results ① In iodine density of1 000 ug/L, the proliferation rate of fibroblasts in combination group was(1.06 ± 0.13), which was higher than that in FGFR inhibitor group(0.40 ± 0.12) and lower than that in KI group(1.73 ± 0.09), the difference was statistically significan(P 0.05). ② The FGFR2 protein expression level of fibroblasts in iodine density of 500 ug/L and 1 000 ug/L was higher than those in other iodine densities. The FGFR2 protein expression level in 1 000 ug/L group was higher than that in 500 ug/L group (P 0.05). The difference in bFGF protein expression level between each other group was not significant(P 0.05). Conclusion ① High density of iodine may promote the proliferation of fibroblasts by adjusting the protein expression level of FGFR2 upward. ② The proliferation of fibroblasts caused by high iodine density may result in the formation of membrane in Budd-Chiari syndrome." @default.
- W2356561710 created "2016-06-24" @default.
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- W2356561710 date "2013-01-01" @default.
- W2356561710 modified "2023-09-26" @default.
- W2356561710 title "Research on the relationship between bFGF, FGFR2 and the fibroblast proliferation promoted by high density iodine" @default.
- W2356561710 hasPublicationYear "2013" @default.
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