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- W2356562405 abstract "To investigate the effects of Ganoderma lucidum polysaccharides(GLPS) on the protection of rat primary dopaminergic neurons induced by lipopolysaccharides(LPS).【Methods】 We co-cultured the rat primary neuron-glia.The co-cultured cells were divided into 6 groups(n=5): control group,LPS group(20 ng/mL),GLPS group and LPS+GLPS(50,100,300 nɡ/mL)group.The positive cells of TH,ox-42 and the expression of TNF-α mRNA and iNOS mRNA were observed by immunohistochemistry and RT-PCR.【Results】 The numbers of TH positive neurons in the groups of GLPS(100 nɡ/mL,300 nɡ/mL) were more than those in LPS group(30.1±3.1,34.2±3.2,23.4±2.8).The microglia can be activated by LPS and the total number of microglia was increased(30.6±4.5).The expression of TNF-α mRNA and iNOS mRNA was increased.Pretreatment with GLPS(100 nɡ/mL,300 nɡ/mL) could block LPS-induced activated microglia and the total number of microglia was also decreased(26.4±5.1,25.1±4.6).Consequently the expression of TNF-α mRNA and iNOS mRNA was also significantly inhibited(P0.01).【Conclusion】 Pretreatment with GLPS could protect the rat primary DA neurons induced by LPS.The effects may be contributed to GLPS-blocked activity of microglia induced by LPS and reduced the expression of TNF-α mRNA and iNOS mRNA." @default.
- W2356562405 created "2016-06-24" @default.
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- W2356562405 date "2006-01-01" @default.
- W2356562405 modified "2023-09-28" @default.
- W2356562405 title "Ganoderma Lucidum Polysaccharides Protects Rat Primary Dopaminergic Neurons Induced by Lipopolysaccharides" @default.
- W2356562405 hasPublicationYear "2006" @default.
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