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- W2356562836 abstract "To investigate the effect of combined usage of FTY720 and CsA on the blood system and lymphoid organs,FTY720,CsA and FTY720 plus CsA were administrated to the Kuming strains of mice for two weeks and the numbers of peripheral lymphocytes and granulocytes,hemoglobulin and the weight of thymus,spleen and bone marrow were determined during the course of administration and after cessation of application of drugs It was found that the numbers of peripheral lymphocytes significantly reduced 1～2 weeks after administration of FTY720 and the combined use of these two drugs It gradually recovered after cessation of drugs As to the peripheral granulocytes and hemoglobulin as well as the weights of thymus and bone marrow,there was no significant changes in all groups either during administrations or after cessation of drugs,yet,weight of spleen decreased significantly either 2 weeks after administration or 4 weeks after cessation of drugs These results suggest that FTY720 can selectively delete mature lymphocytes,but CsA has no significant influence on the effect of FTY720,indicating that the immunosuppressive effect of combined usage of FTY720 and CsA might be expressed through different mechanisms" @default.
- W2356562836 created "2016-06-24" @default.
- W2356562836 creator A5063481044 @default.
- W2356562836 date "2001-01-01" @default.
- W2356562836 modified "2023-09-26" @default.
- W2356562836 title "Effect of Combined Usages of FTY720 and CsA on Blood and Lymphoid Organs" @default.
- W2356562836 hasPublicationYear "2001" @default.
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