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- W2356566427 abstract "Objective:To investigate the expression of p27kip1 in gastric carcinoma and its relationship with clinical pathological factors.Methods: Expressions of p27kip1 in 60 specimens of gastric carcinoma,carcinoma tissue,adjacent mucosa tissue and distant normal mucosa tissue were studied using a two-step method of EnVision immunohistochemical system.The numerical densities of total parenchymal cells and the p27kip1-positive cells were measured by image analysis,and the positive rates were caculated.Results: The expression of p27kip1 in the carcinoma tissue was significantly lower than that in distant normal mucosa,but did not differ from that in the adjacent mucosa tissue significantly.The expression level of p27kip1 in carcinoma tissue was correlated significantly with the differentiation grade,invasive depth,and local lymph node metastasis.Conclusion: Since the expression level of p27kip1 in carcinoma tissue correlates with some biological features of the tumor,it may be considered as a marker of prognostic significance;the decline of p27kip1 expression in the adjacent tissue might play a role in the invasion and metastasis of the tumor." @default.
- W2356566427 created "2016-06-24" @default.
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- W2356566427 date "2007-01-01" @default.
- W2356566427 modified "2023-09-22" @default.
- W2356566427 title "The Expression of p27~(kip1) in Human Gastric Carcinoma and the Adjacent Mucous Tissue and Its Significance in Prognosis" @default.
- W2356566427 hasPublicationYear "2007" @default.
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