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- W2356572057 abstract "Objective To detect possible etiological origin for cryptogenic infantile spasms (IS) in terms of gray matter volume by using voxel-based morphometry (VBM) method. Methods High resolution structural brain MR images were derived from 16 infants (mean aged 6.4 month) having IS and 16 matched normal infants. Image data were analyzed by SPM software using VBM method, including an automated segmentation procedure and standardized parametric statistics. Whole brain gray matter volumes were compared between 2 groups. Results In comparison with normal infants, the IS group showed significantly decreased gray matter volume in left inferior frontal gyrus, right superior temporal gyrus, left posterior central gyrus, right middle frontal gyrus, right precentral gyrus, right callosal gyrus, left middle temporal gyrus and left superior temporal gyrus (Bradmann area 47, 22, 1-2, 9/10, 6, 31, 21, and 38) (P0.001, uncorrected). Conclusion Structural abnormalities in the frontal and temporal lobe cortex in infants with IS might be the possible mechanism for cryptogenic IS in the studied group." @default.
- W2356572057 created "2016-06-24" @default.
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- W2356572057 date "2006-01-01" @default.
- W2356572057 modified "2023-09-25" @default.
- W2356572057 title "Voxel-based morphometry of gray matter structure in normal infants and infants with cryptogenic infantile spasms" @default.
- W2356572057 hasPublicationYear "2006" @default.
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