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- W2356575431 abstract "Objective To synthesize levetiracetam and to improve the synthesis process. Methods Levetiracetam,as a new antiepileptic drug,was synthesized from(S)-2-aminobutyric acid via esterification and aminolysis to give(S)-2-aminobutyramide hydrochloride,which was subjected to condensation with 4-chloride butyryl chloride,and then cyclized intramolecularly.Results The total yield of levetiracetam was 46.6%,the purity was 99.75%(high performance liquid chromatography),and its structure was confirmed by elemental analysis(EA),mass spectrum(MS) and H NMR spectroscopy. Conclusion The synthetic route for levetiracetam was convenient for industrial manufacture with simple operation and high yield." @default.
- W2356575431 created "2016-06-24" @default.
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- W2356575431 date "2013-01-01" @default.
- W2356575431 modified "2023-09-23" @default.
- W2356575431 title "SYNTHESIS OF LEVETIRACETAM" @default.
- W2356575431 hasPublicationYear "2013" @default.
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