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- W23565770 endingPage "230" @default.
- W23565770 startingPage "211" @default.
- W23565770 abstract "A comprehensive review of the current state of clinical biological marker (biomarker) research, specifically in terms of both the analytical and preanalytical factors influencing their discovery, development, validation, and clinical translation is provided. In this manuscript, significant discussion is devoted to the issues surrounding sample pretreatment and the appropriate collection of biomarker-specific biological fluids (i.e., plasma, serum, urine, cerebrospinal fluid, and human tissue). Advantages and limitations of biofluid types, fluid-specific pretreatments, and the in vitro impact of sample processing on biomarker analyses are also presented. The context and fundamental importance of incorporating such sample considerations into biomarker experimental design is provided through a review of current biomarker interests, academic outputs, and translational difficulties. Previously proposed developmental frameworks and validation schemas are also presented in an attempt to bridge the translational chasm that currently exists between the discovery of a putative indicator and its clinical implementation. Collectively, this work aims to provide researchers, within both the basic and clinical sciences, a comprehensive resource for which enhanced future biomarker studies may be based." @default.
- W23565770 created "2016-06-24" @default.
- W23565770 creator A5031969295 @default.
- W23565770 date "2012-01-01" @default.
- W23565770 modified "2023-09-27" @default.
- W23565770 title "Issues and Pitfalls in Biomarker Development and Clinical Relevance" @default.
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