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- W2356586803 abstract "Objective To study by in vitro experiment the effects of human cytomegalovirus(HCMV)infection on human sperm viability,movement parameters and its ultramicrostructure.Methods HCMV was co-cultured in vitro with normal human sperms optimized by using swim-up technique in 10 persons.The samples were collected at hours 0,1,2,3 and 4,separately.The sperm viability was detected.Computer-aided semen analysis (CASA) was employed to measure the sperm velocity straight linear (VSL),velocity curve linear (VCL),velocity average path (VAP),amplitude of lateral head displacement (ALH),and progressive motility (percentage of a+b sperms).At the same time,the changes of human sperm ultrastructures in different periods of in vitro infection were observed under the electron microscopy.Results The viability of human sperms infected with high concentration HCMV for 1,3 h was significantly declined in comparison with the corresponding blank and negative control groups (P0.05),and at h 4,the difference was very significant (P0.001).The sperm progressive motility was significantly reduced at h 4 after high concentration HCMV infection (P0.05).At different time points,there was no significant difference in VSL between the two groups (P0.05).At h 3 after high concentration HCMV infection,VCL was significantly decreased (P0.05),and at 4 h,the difference was very significant (P0.001).At h 4 after moderate concentration HCMV infection,sperm VCL was also decreased (P0.05).The VAP was significantly reduced at hours 2,3 and 4 after high-moderate concentration HCMV infection (P0.05).At hours 3 and 4 after high concentration HCMV infection,ALH was significantly reduced (P0.05).Microscopy revealed that no significant changes in the sperm ultrastructure at hours 2 and 4 between the blank and negative control groups.The abnormal changes in the sperm ultrastructure in the high concentration HCMV group were commonly seen,severer at hour 4,and the main lesions included sperm nuclear depolymerization,increased vacuoles,acrosome rupture,damage to cytoplasmic membrane,swelling and irregular arrangement of mitochondria.Conclusions In vitro HCMV infection for 3～4 h induces the abnormality of sperm viability,some movement parameters,and sperm ultrastructures,and the change has some dose-effect relationship with the concentration of HCMV.High HCMV infection significantly affects the sperm function and ultrastructure." @default.
- W2356586803 created "2016-06-24" @default.
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- W2356586803 date "2008-01-01" @default.
- W2356586803 modified "2023-09-25" @default.
- W2356586803 title "Effect of cytomegalovirus infection on human sperm viability,movement parameters and ultramicrostructure in vitro" @default.
- W2356586803 hasPublicationYear "2008" @default.
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