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- W2356606471 abstract "Objective:to study the effect of Panax Notogenseng on the COX-2 expression in liver of rats with Alcoholic Fatty Liver.Methods:62 SD rats were randomly divided into the normal, the model and three treatment groups, except the rats of the normal,the rats in the other groups were given of 50% alcohol by daily gavage and drank 10% alcoholic beverage with freedom, all the rats in the treatment groups were intervened with the relevant drugs. After 14 week, the rats were killed and the their pathologic changes were observed, the COX-2 expression of liver was detected with immunohistochemical method , the amounts of TXB2 and 6-Keto-PGF1α with RIA.Conclusion:different degree steatosis appeared in the liver tissue in the model group, the COX-2 expression of rat liver was significantly increased than that in the normal, the amounts of plasma TXB2,6-Keto-PGF1α and the ratio of TXB2/6-Keto-PGF1α were obviously higher than that in the normal. After the treatment with different dose of Panax Notogenseng, the steatosis became lightened, the COX-2 expression was significantly decreased , the amounts of plasma TXB2,6-Keto-PGF1α and the ratio of TXB2/6-Keto-PGF1α were obviously lower.Results:Panax Notogenseng can improve the microcirculation of rats with alcoholic fatty liver and repress the COX-2 expression of model rats, which may be the one of mechanisms of anti-alcoholic fatty live treated with Panax Notogenseng." @default.
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- W2356606471 date "2007-01-01" @default.
- W2356606471 modified "2023-09-28" @default.
- W2356606471 title "Effect of Panax Notogenseng on the COX-2 Expression in Liver of Rats with Alcoholic Fatty Liver" @default.
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