Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356606979> ?p ?o ?g. }
- W2356606979 abstract "OZET Molekuler genetikteki ilerlemelere ramen, bipolar bozuk- luk (BP) ve flizofreniden (fi) sorumlu genler belirleneme- mifltir. Bunun nedenleri aras›nda fenotip tan›mlamalar› ile ilgili sorunlar ve hastal›klar›n kal›t›m kal›plar› ile ilgili farkl› mekanizmalar say›labilir. Fenotip tan›mlamalar› ile ilgili so- runlar›n afl›labilmesi ve risk art›r›c› ya da koruyucu etkisi bulunan genlerin belirlenmesi icin endofenotip yaklafl›m› onerilmektedir. Eflik-alt› yatk›nl›k gostergeleri olarak ta- n›mlanabilecek endofenotipler, hasta olma durumundan ba¤›ms›z olarak genetik alt yap›y› anlamay› kolaylaflt›rabi- lirler. Endofenotip yaklafl›m›nda BP ve fi tan›lar›na k›yasla, patofizyoloji ve genetik etiyoloji ile daha yak›ndan iliflkili, daha basit genetik temelleri olan ve daha iyi tan›mlanm›fl fenotiplerin bulunmas› amaclanmaktad›r. Endofenotipler kal›tsal norofizyolojik, noropsikolojik, biliflsel, noroanato- mik, biyokimyasal ya da endokrinolojik ozellikler olabilir. Ancak i. hastal›kla iliflkili olmas›, ii. hasta olmayan aile bi- reylerinde genel toplumdan daha yuksek oranda gorulme- si, iii. genel toplumda belli bir oranda bulunmas› ve iv. hastal›k durumundan ba¤›ms›z (trait marker) olmas› ge- reklidir. Endofenotip yaklafl›m› cok genli/cok etkenli hasta- l›klar olan BP ve fi'de genotip-fenotip aras›ndaki yorday›c› iliflkiyi ve genetik analizlerin gucunu art›rmak d›fl›nda, s›- n›fland›rma sistemlerinin ve tan› kategorilerinin yeniden flekillendirilebilmesini ve hayvan modellerinin gelifltirilme- sini salayabilir. Bu yaz›da BP ve fi ile ilgili genetik cal›fl- malarda endofenotip yaklafl›m›na gereksinim yaratan o¤e- ler ve one surulen aday endofenotipler gozden gecirilerek, her iki hastal›kta bu yaklafl›m ile saptanabilen bulgular ak- tar›lm›flt›r." @default.
- W2356606979 created "2016-06-24" @default.
- W2356606979 creator A5002669173 @default.
- W2356606979 creator A5013603043 @default.
- W2356606979 date "2004-01-01" @default.
- W2356606979 modified "2023-09-24" @default.
- W2356606979 title "Bipolar Bozukluk ve Şizofreni Genetiğindeki Sorunlar›n Giderilmesinde Endofenotip Yaklaş›m›n›n Yeri" @default.
- W2356606979 cites W127955425 @default.
- W2356606979 cites W1521672192 @default.
- W2356606979 cites W1533951045 @default.
- W2356606979 cites W1587235330 @default.
- W2356606979 cites W1900259029 @default.
- W2356606979 cites W1965146482 @default.
- W2356606979 cites W1965148748 @default.
- W2356606979 cites W1967208968 @default.
- W2356606979 cites W1967443916 @default.
- W2356606979 cites W1968250702 @default.
- W2356606979 cites W1968524760 @default.
- W2356606979 cites W1973620160 @default.
- W2356606979 cites W1973947372 @default.
- W2356606979 cites W1976130946 @default.
- W2356606979 cites W1979038244 @default.
- W2356606979 cites W1983695475 @default.
- W2356606979 cites W1985974491 @default.
- W2356606979 cites W1986499195 @default.
- W2356606979 cites W1988281657 @default.
- W2356606979 cites W1990841563 @default.
- W2356606979 cites W1994147836 @default.
- W2356606979 cites W1996395058 @default.
- W2356606979 cites W1997038056 @default.
- W2356606979 cites W2000165044 @default.
- W2356606979 cites W2000628954 @default.
- W2356606979 cites W2002735350 @default.
- W2356606979 cites W2003078612 @default.
- W2356606979 cites W2005000985 @default.
- W2356606979 cites W2005084403 @default.
- W2356606979 cites W2007986510 @default.
- W2356606979 cites W2008300370 @default.
- W2356606979 cites W2009178977 @default.
- W2356606979 cites W2010228224 @default.
- W2356606979 cites W2012403108 @default.
- W2356606979 cites W2013437959 @default.
- W2356606979 cites W2016817230 @default.
- W2356606979 cites W2020156455 @default.
- W2356606979 cites W2020528297 @default.
- W2356606979 cites W2021404482 @default.
- W2356606979 cites W2027977900 @default.
- W2356606979 cites W2031118642 @default.
- W2356606979 cites W2032139509 @default.
- W2356606979 cites W2032866243 @default.
- W2356606979 cites W2034285947 @default.
- W2356606979 cites W2035161704 @default.
- W2356606979 cites W2035960312 @default.
- W2356606979 cites W2043567599 @default.
- W2356606979 cites W2048329911 @default.
- W2356606979 cites W2048648661 @default.
- W2356606979 cites W2049367879 @default.
- W2356606979 cites W2050518297 @default.
- W2356606979 cites W2050626277 @default.
- W2356606979 cites W2051356409 @default.
- W2356606979 cites W2056272943 @default.
- W2356606979 cites W2058673739 @default.
- W2356606979 cites W2070287401 @default.
- W2356606979 cites W2070628135 @default.
- W2356606979 cites W2071128065 @default.
- W2356606979 cites W2077439273 @default.
- W2356606979 cites W2078774097 @default.
- W2356606979 cites W2079293160 @default.
- W2356606979 cites W2079730191 @default.
- W2356606979 cites W2082743790 @default.
- W2356606979 cites W2082863478 @default.
- W2356606979 cites W2086064751 @default.
- W2356606979 cites W2086958458 @default.
- W2356606979 cites W2087495118 @default.
- W2356606979 cites W2088376011 @default.
- W2356606979 cites W2090979638 @default.
- W2356606979 cites W2094630986 @default.
- W2356606979 cites W2095251402 @default.
- W2356606979 cites W2103475051 @default.
- W2356606979 cites W2108177777 @default.
- W2356606979 cites W2111012336 @default.
- W2356606979 cites W2114455511 @default.
- W2356606979 cites W2117593067 @default.
- W2356606979 cites W2118310978 @default.
- W2356606979 cites W2124318039 @default.
- W2356606979 cites W2125513309 @default.
- W2356606979 cites W2127057918 @default.
- W2356606979 cites W2132406375 @default.
- W2356606979 cites W2137214935 @default.
- W2356606979 cites W2142807256 @default.
- W2356606979 cites W2143422704 @default.
- W2356606979 cites W2143881724 @default.
- W2356606979 cites W2144671685 @default.
- W2356606979 cites W2145785866 @default.
- W2356606979 cites W2146299064 @default.
- W2356606979 cites W2146738944 @default.
- W2356606979 cites W2148234967 @default.
- W2356606979 cites W2148477876 @default.
- W2356606979 cites W2149470049 @default.
- W2356606979 cites W2150090706 @default.