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- W2356634802 abstract "AIM: To investigate whether hypercapnia is protective against acute lung injury (ALI) in a rabbit model, and study it's potential mechanisms. METHODS: Twenty-two healthy New Zealand white rabbits were involved in this study, and randomly allocated to control group (group C), normocapnic group (group N) and hypercapnic group (group H). Oleic acid (0 1 mL/kg) was injected intravenously to establish ALI model. Lung mechanics, hemodynamics, blood-gas analysis, the content of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in lung tissue were measured. Apoptosis was analyzed after 3h mechanical ventilation. RESULTS: (1) Peak airway pressure in group H was significantly lower than that in group N (P0 05) and the dynamic lung compliance was significantly higher than that in group N (P0 05). (2) PaO 2 in group H was significantly higher than that in group N(P0 05). (3) The content of MDA was significantly lower but the activity of SOD was significantly higher in group H than that in group N (P0 05). (4) Apoptosis index in group H was significantly lower than that in group N (P0 01). (5) Histologic damage was significantly severer in group N than group H. (6) PaCO 2 was correlated with pH, PaO 2, dynamic lung compliance, peak airway pressure and pulmonary permeability index (r=-0 928, P0 01; r=0 511, 0 526, -0 506, -0 556, P0 05, respectively). CONCLUSION: Hypercapnia protects lung from oleic acid-induced injury in rabbits. The mechanisms of protection might be associated with improvement of oxidation/anti-oxidation imbalance and inhibition of apoptosis." @default.
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- W2356634802 date "1989-01-01" @default.
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- W2356634802 title "Protective effects of hypercapnia on acute lung injury and it's mechanisms" @default.
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