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- W2356636595 abstract "Objective:To investigate the effect o f IL-2 on the proliferation of rat uterin smooth muscle cells and explore its possible mechanism. Methods: Enha ncement effect of IL-2 on proliferation of cultured rat uterin smooth muscle cel ls, the effect of IL-2 on DNA content at various periods of cell cycle and on Ca 2+ concentration in the cells and the expression of interleukin-2 receptor s were detected or observed by MTT colorimetry, flow cytometry, laser scanning confoca l microscope and RT-PCR, respectively. Results:I L-2 of 10 to 1 000 U/ml signific antly stimulated the proliferation of cultured rat uterin smooth muscle cells. I L-2(100 U/ml) increased the ratio of rat uterin smooth muscle cells in G 1 and S phas es and increased the Ca 2+ release from rat uterin smooth muscle cells. Conclusion:IL-2 significantly enhanced the proliferation of rat uterin smooth muscle ce lls. The enhancement effect of IL-2 on rat uterin smooth muscle cell proliferati on is possibly related to the altering of DNA content, increased Ca 2+ conc entration and expression of interleukin-2 receptors in the cells." @default.
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- W2356636595 date "2004-01-01" @default.
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- W2356636595 title "Enhancement effect of interleukin-2 on the proliferation of cultured rat uterin smooth muscle cells and the expression of interleukin-2 receptors" @default.
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