Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356683555> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2356683555 endingPage "708" @default.
- W2356683555 startingPage "708" @default.
- W2356683555 abstract "Objective Many clinical studies indicated that Helicobacter pylori(Hp)strains rarely acquired resistance to amoxicillin but easily to clarithromycin and metronidazole.However,it was unclear whether the antibiotic resistance of Hp strains was induced or passively selected during long-term or frequent treatment with metronidazole,clarithromycin and amoxicillin.To compare the propensity of acquired resistance to antibiotics,Hp strains were exposed to amoxicillin,clarithromycin and metronidazole in vitro in this study.Methods All Hp strains were clinical isolates,derived from biopsy specimens of patients taken during endoscopy in the Affiliated Children's Hospital,Zhejiang University School of Medicine from December 2004 to July 2005.To seek susceptible strains,the minimum inhibitory concentrations(MICs)of the three antibiotics were determined by using Epsilometer test(E-test)method.In vitro induction was carried out on serially doubling concentrations of antibiotics incorporated into agar.Isolates were also transferred at least three times on antimicrobial agent-free medium,followed by a redetermination of the final MICs to assess the stability of the selected resistance.Results 7 strains were exposed to antibiotics in vitro.After 6-17 passages on antibiotic plates,7 and 3 strains respectively acquired resistance to metronidazole and clarithromycin,while none of the strains were resistant to amoxicillin.The inductive folds were different among three groups:8-128 folds in metronidazole group;1-256 folds in clarithromycin group; 2-16 folds in amoxicillin group.After three transfers on antimicrobial agent-free medium,the MICs decreased significantly in amoxicillin group(P0.05)but had no change in metronidazole group and clarithromycin group(P0.05).Conclusions The metronidazole resistance in Hp was easily selected. Strains resistant to clarithromycin could be selected,but the amoxicillin resistance could not be selected after in vitro induction for Hp isolated from children.The correlation between in vitro and in vivo outcomes suggests that acquired resistance was the main cause for the resistance in Hp strains.The laboratory results of in vitro antibiotic induction could help predict the actual rate of resistance and select appropriate antibiotics for treatment." @default.
- W2356683555 created "2016-06-24" @default.
- W2356683555 creator A5008579191 @default.
- W2356683555 creator A5008779074 @default.
- W2356683555 creator A5047519564 @default.
- W2356683555 creator A5062109942 @default.
- W2356683555 creator A5065408488 @default.
- W2356683555 creator A5065648855 @default.
- W2356683555 date "2007-09-01" @default.
- W2356683555 modified "2023-09-24" @default.
- W2356683555 title "[Preliminary study on in-vitro induction of antibiotic resistance in Helicobacter pylori strains isolated from children]." @default.
- W2356683555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18021568" @default.
- W2356683555 hasPublicationYear "2007" @default.
- W2356683555 type Work @default.
- W2356683555 sameAs 2356683555 @default.
- W2356683555 citedByCount "1" @default.
- W2356683555 countsByYear W23566835552017 @default.
- W2356683555 crossrefType "journal-article" @default.
- W2356683555 hasAuthorship W2356683555A5008579191 @default.
- W2356683555 hasAuthorship W2356683555A5008779074 @default.
- W2356683555 hasAuthorship W2356683555A5047519564 @default.
- W2356683555 hasAuthorship W2356683555A5062109942 @default.
- W2356683555 hasAuthorship W2356683555A5065408488 @default.
- W2356683555 hasAuthorship W2356683555A5065648855 @default.
- W2356683555 hasConcept C126322002 @default.
- W2356683555 hasConcept C2776409635 @default.
- W2356683555 hasConcept C2776962512 @default.
- W2356683555 hasConcept C2777396551 @default.
- W2356683555 hasConcept C2779708577 @default.
- W2356683555 hasConcept C4937899 @default.
- W2356683555 hasConcept C501593827 @default.
- W2356683555 hasConcept C71924100 @default.
- W2356683555 hasConcept C86803240 @default.
- W2356683555 hasConcept C89423630 @default.
- W2356683555 hasConcept C94665300 @default.
- W2356683555 hasConceptScore W2356683555C126322002 @default.
- W2356683555 hasConceptScore W2356683555C2776409635 @default.
- W2356683555 hasConceptScore W2356683555C2776962512 @default.
- W2356683555 hasConceptScore W2356683555C2777396551 @default.
- W2356683555 hasConceptScore W2356683555C2779708577 @default.
- W2356683555 hasConceptScore W2356683555C4937899 @default.
- W2356683555 hasConceptScore W2356683555C501593827 @default.
- W2356683555 hasConceptScore W2356683555C71924100 @default.
- W2356683555 hasConceptScore W2356683555C86803240 @default.
- W2356683555 hasConceptScore W2356683555C89423630 @default.
- W2356683555 hasConceptScore W2356683555C94665300 @default.
- W2356683555 hasIssue "9" @default.
- W2356683555 hasLocation W23566835551 @default.
- W2356683555 hasLocation W23566835552 @default.
- W2356683555 hasOpenAccess W2356683555 @default.
- W2356683555 hasPrimaryLocation W23566835551 @default.
- W2356683555 hasRelatedWork W1568115877 @default.
- W2356683555 hasRelatedWork W1909007159 @default.
- W2356683555 hasRelatedWork W1924404163 @default.
- W2356683555 hasRelatedWork W2024810618 @default.
- W2356683555 hasRelatedWork W2047975024 @default.
- W2356683555 hasRelatedWork W2064888453 @default.
- W2356683555 hasRelatedWork W2083533110 @default.
- W2356683555 hasRelatedWork W2130569918 @default.
- W2356683555 hasRelatedWork W2159286050 @default.
- W2356683555 hasRelatedWork W2183784058 @default.
- W2356683555 hasRelatedWork W2355553258 @default.
- W2356683555 hasRelatedWork W2373806999 @default.
- W2356683555 hasRelatedWork W2375560362 @default.
- W2356683555 hasRelatedWork W2735899764 @default.
- W2356683555 hasRelatedWork W2897321431 @default.
- W2356683555 hasRelatedWork W2957197024 @default.
- W2356683555 hasRelatedWork W2978590446 @default.
- W2356683555 hasRelatedWork W3029301319 @default.
- W2356683555 hasRelatedWork W3117469233 @default.
- W2356683555 hasRelatedWork W3181101287 @default.
- W2356683555 hasVolume "45" @default.
- W2356683555 isParatext "false" @default.
- W2356683555 isRetracted "false" @default.
- W2356683555 magId "2356683555" @default.
- W2356683555 workType "article" @default.