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- W2356693645 abstract "The patients with type 1 or 2 diabetes mellitus have increased risk of osteoporosis and osteoporotic fractures significantly.The mechanism that induces diabetic osteoporosis may be due to the exhaust of bone marrow mesenchymal stem cells(BMSCs).It is apparent that hyperglycemia and varied factors in diabetes directly suppresses osteoblast-mediated bone formation and function,while conversely promoting adipogenic differentiation of BMSCs,and fat accumulation in the marrow cavity,all of which decrease the quantity of osteoblasts used for bone formation.Especially,the peroxisome proliferator-activated receptors γ is a gate-keeper for BMSCs differentiation into adipocytes and osteoblasts.Because diabetes mainly affects bone density by decreasing bone formation rather than increasing bone resorption,logically,it should be a most basic method to prevent and treat the diabetes induced osteoporosis by increasing osteoblasts and inhibiting the pathway of BMSCs differentiation toward adipocytes." @default.
- W2356693645 created "2016-06-24" @default.
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- W2356693645 date "2012-01-01" @default.
- W2356693645 modified "2023-09-27" @default.
- W2356693645 title "Effects of Bone Marrow Mesenchymal Stem Cells on Diabetic Osteoporosis" @default.
- W2356693645 hasPublicationYear "2012" @default.
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