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- W2356698829 abstract "Objective To investigate the effect of 15-Lipoxygenase-1(15-LOX-1) on cell cycle of gastric carcinoma and to evaluate its mechanism.Methods The human gastric carcinoma cell line AGS were divided into three groups: 15-LOX-1 transfected group,empty plasmid transfected control group and liposome treated group.The expression of 15-LOX-1 mRNA and protein were detected by semiquantitive RT-PCR and Western blot,respectively.The distribution of cell cycle was evaluated by flow cytometry(FCM).The expression of S-phase Kinase-associated protein 2(Skp2) and P27 were detected by Western blot.Results Compared with the empty plasmid transfected control group and liposome treated group,RT-PCR and Western blot both showed the expression of 15-LOX-1 was detected from 15-LOX-1 transfected group.The FCM results shows that 15-LOX-1 could resort a majority of gastric carcinoma cell AGS in period G0/G1 rather than enter the period S,so that the proportion of S period fell.In addition,P27 was up-regulated,meanwhile,Skp2 was down-regulated(P0.05).Conclusion 15-LOX-1 can effectively regulate the expression of Skp2 and P27 to resort gastric carcinoma cell in period G0/G1 and inhibit carcinoma cell proliferation." @default.
- W2356698829 created "2016-06-24" @default.
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- W2356698829 date "2010-01-01" @default.
- W2356698829 modified "2023-09-22" @default.
- W2356698829 title "Effect of 15-Lipoxygenase-1 on cell cycle of gastric carcinoma and its mechanism" @default.
- W2356698829 hasPublicationYear "2010" @default.
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