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- W2356702007 abstract "Aim To design and synthesize some 3-substituted benzoyl-4H-chromen-4-ones and to evaluate their antimycobacterial activity.Methods The target compounds were synthesized from 1,2,3-benzene triol and substituted benzoic acid via Friedel-Crafts acylation and Baker-Venkataraman rearrangement,etc.Their MICs of in vitro antimycobacterial activity were determined.Results Eight compounds not reported were synthesized and their structures were confirmed by 1H-NMR and MS.Compounds 2a and 2e had weak antimycobacterial activity.Conclusion The introduction of carbon-carbon double bond in position 2,methoxy groups in position 7,8 and carbonyl group in position 9 in the natural product 3-(4-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one would lead the decrease of antimycobacterial activity." @default.
- W2356702007 created "2016-06-24" @default.
- W2356702007 creator A5020601988 @default.
- W2356702007 date "2009-01-01" @default.
- W2356702007 modified "2023-09-26" @default.
- W2356702007 title "Synthesis and antimycobacterial activity of 3-substituted benzoyl-4H-chromen-4-ones" @default.
- W2356702007 hasPublicationYear "2009" @default.
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