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- W2356719642 abstract "Objective:To select a series of HCV T cell epitopes highly conserved and multiple MHC supertype_restricted and to construct their expression plasmids.Methods:HCV T cell epitopes were selected from the published literature.By using the Goldkey software, a database containing whole HCV protein sequence was constructed and then all the selected epitopes were compared in this database. The highly conserved epitopes were selected and their genes were inserted into the expression vector pBVIL1 and expressed in E.coli .Results: Eighteen T cell epitopes were acquired from literature altogether. After comparing these epitopes in database including 55 HCV whole protein sequences,their homologies were clearly defined and the statistic analyses about all the epitopes were done.After testing, the epitope genes were proved to be inserted correctly into the vector and were expressed in E.coli highly.Conclusions:This work will do good to the awareness of the specialty of the T cell epitopes and will provide the methodology reference on the selection of the epitopes. It also paves the way of the study for the HCV therapeutic vaccination." @default.
- W2356719642 created "2016-06-24" @default.
- W2356719642 creator A5064185144 @default.
- W2356719642 date "2003-01-01" @default.
- W2356719642 modified "2023-09-25" @default.
- W2356719642 title "T-Cell antigenic epitopes of hepatitis C virus:selecting,cloning and expressing in E.coli" @default.
- W2356719642 hasPublicationYear "2003" @default.
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