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- W2356720074 abstract "Objective:To investigate the effects of controlled hypotension with isoflurane anaesthesia during endoscopic sinus surgery and its mechanism.Methods:A total of 200 ASA Ⅰ-Ⅱ patients that were scheduled for endoscopic sinus surgery were enrolled in this study.At the early stage,nitroglycerin 1μg.kg-1.min-1 was injected at an increased speed until the mean arterial pressure(MAP)was 55-65mmHg,when the heart beat was more than 100 times/min,intravenous esmolol was given to control it under 90times/min,then concentration of the inhaled isoflurane was increased to be 1.5%-2.0%,meanwhile,rate of nitroglycerin infusion was reduced.Stress reflex sensitivity(BRS)was measured 10 and 30 minutes after the withdrawal of nitroglycerin and esmolol,as well as under different concentration of isoflurane(end-tidal value).Results:When the end-tidal isoflurane concentration was 1.5%,(30±15)min,the infusion of esmolol and nitroglycerin was withdrawaled.BRS decreased with the end-tidal isoflurane concentration with significant difference between different time points(P0.05 or 0.01).Conclusions:When deep anesthesia is induced by isoflurane or BRS is depressed,well controlled hypotension can be achieved for endoscopic sinus surgery." @default.
- W2356720074 created "2016-06-24" @default.
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- W2356720074 date "2010-01-01" @default.
- W2356720074 modified "2023-09-26" @default.
- W2356720074 title "Effects of controlled hypotension with isoflurane anaesthesia during endoscopic sinus surgery" @default.
- W2356720074 hasPublicationYear "2010" @default.
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