Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356722182> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2356722182 abstract "Objective To investigate the regulation of renal cortical cyclooxygenase-2 expression in rats with adriamycin nephrosis. Methods The rats were randomly assigned to following groups: control, adriamycin nephrosis (ADR), ADR treated with rofecoxib (10 mg ?kg-1 ?d-1), ADR treated with indomethacin (2 mg ?kg-1 ?d-1), ADR treated with losartan (100 mg ?kg-1 ?d-1). The urinary protein and thromboxane 82 as well as cortical angiotensin II were measured after eight weeks. The expression of cortical COX2 and COX1 was detected by immunohistochemistry, RT-PCR and Western blotting. Results The rats in group ADR developed nephrotic syndrome characterized by heavy proteinuria and COX2 expression and TXB2 excretion were significantly increased while COX1 expression remained undisturbed in comparison with those in the normal control group. The level of angiotensin II in cortex was increased. Rofecoxib significantly down-regulated COX2 expression accompanied with TXB2 excretion decreased while COX1 expression remained undisturbed. Indomethacin significantly decreased both of COX2 and COX1 expression. However losartan had no effect on the expression of COX2 and COX1. Conclusions COX2 expression and TXB2 excretion are significantly increased in rats with adriamycin nephrosis while COX1 expression remains undisturbed. Rofecoxib down-regulates COX2 expression and partly inhibits the activation of renal renin-angiotensin system." @default.
- W2356722182 created "2016-06-24" @default.
- W2356722182 creator A5054297733 @default.
- W2356722182 date "2003-01-01" @default.
- W2356722182 modified "2023-09-24" @default.
- W2356722182 title "Expression and regulation of renal cortical cyclooxygenase-2 in rats with adriamycin nephrosis" @default.
- W2356722182 hasPublicationYear "2003" @default.
- W2356722182 type Work @default.
- W2356722182 sameAs 2356722182 @default.
- W2356722182 citedByCount "0" @default.
- W2356722182 crossrefType "journal-article" @default.
- W2356722182 hasAuthorship W2356722182A5054297733 @default.
- W2356722182 hasConcept C10146269 @default.
- W2356722182 hasConcept C126322002 @default.
- W2356722182 hasConcept C134018914 @default.
- W2356722182 hasConcept C170493617 @default.
- W2356722182 hasConcept C181199279 @default.
- W2356722182 hasConcept C185592680 @default.
- W2356722182 hasConcept C2776785769 @default.
- W2356722182 hasConcept C2778577996 @default.
- W2356722182 hasConcept C2778930706 @default.
- W2356722182 hasConcept C2779561371 @default.
- W2356722182 hasConcept C2779689624 @default.
- W2356722182 hasConcept C2780091579 @default.
- W2356722182 hasConcept C2780288358 @default.
- W2356722182 hasConcept C2781175652 @default.
- W2356722182 hasConcept C2908929049 @default.
- W2356722182 hasConcept C55493867 @default.
- W2356722182 hasConcept C71924100 @default.
- W2356722182 hasConcept C89560881 @default.
- W2356722182 hasConceptScore W2356722182C10146269 @default.
- W2356722182 hasConceptScore W2356722182C126322002 @default.
- W2356722182 hasConceptScore W2356722182C134018914 @default.
- W2356722182 hasConceptScore W2356722182C170493617 @default.
- W2356722182 hasConceptScore W2356722182C181199279 @default.
- W2356722182 hasConceptScore W2356722182C185592680 @default.
- W2356722182 hasConceptScore W2356722182C2776785769 @default.
- W2356722182 hasConceptScore W2356722182C2778577996 @default.
- W2356722182 hasConceptScore W2356722182C2778930706 @default.
- W2356722182 hasConceptScore W2356722182C2779561371 @default.
- W2356722182 hasConceptScore W2356722182C2779689624 @default.
- W2356722182 hasConceptScore W2356722182C2780091579 @default.
- W2356722182 hasConceptScore W2356722182C2780288358 @default.
- W2356722182 hasConceptScore W2356722182C2781175652 @default.
- W2356722182 hasConceptScore W2356722182C2908929049 @default.
- W2356722182 hasConceptScore W2356722182C55493867 @default.
- W2356722182 hasConceptScore W2356722182C71924100 @default.
- W2356722182 hasConceptScore W2356722182C89560881 @default.
- W2356722182 hasLocation W23567221821 @default.
- W2356722182 hasOpenAccess W2356722182 @default.
- W2356722182 hasPrimaryLocation W23567221821 @default.
- W2356722182 hasRelatedWork W180831743 @default.
- W2356722182 hasRelatedWork W2013821641 @default.
- W2356722182 hasRelatedWork W2021599930 @default.
- W2356722182 hasRelatedWork W2036903959 @default.
- W2356722182 hasRelatedWork W2061937172 @default.
- W2356722182 hasRelatedWork W2064227779 @default.
- W2356722182 hasRelatedWork W2081039184 @default.
- W2356722182 hasRelatedWork W2350072693 @default.
- W2356722182 hasRelatedWork W2356528940 @default.
- W2356722182 hasRelatedWork W2359057737 @default.
- W2356722182 hasRelatedWork W2363176635 @default.
- W2356722182 hasRelatedWork W2364848254 @default.
- W2356722182 hasRelatedWork W2378710015 @default.
- W2356722182 hasRelatedWork W2379649579 @default.
- W2356722182 hasRelatedWork W2383586766 @default.
- W2356722182 hasRelatedWork W2385364025 @default.
- W2356722182 hasRelatedWork W2397985435 @default.
- W2356722182 hasRelatedWork W2399271879 @default.
- W2356722182 hasRelatedWork W2587036708 @default.
- W2356722182 hasRelatedWork W3029172948 @default.
- W2356722182 isParatext "false" @default.
- W2356722182 isRetracted "false" @default.
- W2356722182 magId "2356722182" @default.
- W2356722182 workType "article" @default.