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- W2356736150 abstract "Objective To investigate the effects of B7-H1 antisense gene transfection on the biological characteristics of dendritic cells (DCs) in human. Methods Human DCs were transfected with Ad.ASB7-H1 or Ad.LzcZ as positive control, and the untreated DCs served as normal control. Then the phenotypes of DCs, transfected with Ad.ASB7-H1 or Ad.LzcZ or normal, were detected of B7-H1, CD1, CD14, D80, CD83 and HLA-DR, with flow cytometry on post-transfection day 1, 3, 5, 7, 9. Enzyme-linked immunosorbent assay (ELISA) was used to detect IL-12 level of supernatant, 3H-TdR to detect the capacity of the DCs transfected of Ad.ASB7-H1 to activate T lymphocyte proliferation. Results The expression level of B7-H1 on transfected DCs was inhibited from 24 h after transfection, but the expression levels of CD1, CD14, D80, CD83 and HLA-DR were not significantly changed. Ad.ASB7-H1 transfection significantly increased the potency of secretion of IL-12 by transfected DCs and enhanced the ability of DCs to stimulate T cell proliferation. Conclusion DCs transfected by Ad.ASB7-H1 can inhibit B7-H1 expression and the biological characteristics of transfected DCs changed correspondingly. B7-H1 may be a promising target for improving the biological effects of DCs vaccine." @default.
- W2356736150 created "2016-06-24" @default.
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- W2356736150 date "2006-01-01" @default.
- W2356736150 modified "2023-09-26" @default.
- W2356736150 title "Influence on biological characteristics of dendritic cells by transfecting B7-H1 antisense gene" @default.
- W2356736150 hasPublicationYear "2006" @default.
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