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- W2356749783 abstract "Objective: To further determine the frequency and common deletion region of allelic losses on chromosome 8p21～ 23 in lung cancer and facilitate the isolation of the candidate tumor suppressor genes associated with lung cancer. Methods: Using 16 microsatellite markers, we mapped the frequently deleted region on 8p21～ 23 in 2 lung cancer cell lines (1 squamous cell carcinoma and 1 adenocarcinoma) and in 32 surgically resected primary lung tumors (3 small cell lung carcinomas, 13 squamous cell carcinomas, 11 adenocarcinomas and 5 adeno squamous cell carcinomas). Results: Overall, 20 of 34 (58.82％ ) samples showed allelic loss in at least one 8p locus. The most frequent losses of heterozygosity (LOH) occurred at the NEFL and D8s1771 loci (45.16％ , 37.03％ respectively) on chromosome 8p21.1 and at D8s133 locus (35.72％ ) on chromosome 8p21.3. Additionally, 7 cases were observed retaining a continuous allelic loss region between D8s1771 and D8s1477. Conclusion:These data show an interval of common deletion,flanked by D8s1771～ D8s1477 (about 1.5 centi Morgan), might localize a candidate tumor suppressor gene involved in lung carcinogenesis." @default.
- W2356749783 created "2016-06-24" @default.
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- W2356749783 date "2000-01-01" @default.
- W2356749783 modified "2023-09-25" @default.
- W2356749783 title "Fine deletion mapping of chromosome 8p21～ 23 in lung cancer" @default.
- W2356749783 hasPublicationYear "2000" @default.
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