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- W2356756803 abstract "2-[4-(4-Fluorobenzyl) piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine was synthesized from pyrazolo[1,5-a]pyridine-2-carbaldehyde and 1-piperazinecarboxaldehyde through reductive amination,amide hydrosis and N-alkylation.The structures of the intermediates and the target compound were confirmed by 1HNMR,19FNMR and ESI-MS.Through in vitro receptor binding assay,the affinity constants of the target compound were determined to be 1.2,3 900 and 1 890 nmol / L for D4,D2,and D3 receptor,respectively,which indicates that 2-[4-(4-fluorobenzyl) piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine is a potential dopamine D4 receptor ligand." @default.
- W2356756803 created "2016-06-24" @default.
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- W2356756803 date "2013-01-01" @default.
- W2356756803 modified "2023-09-23" @default.
- W2356756803 title "Synthesis of 2-[4-( 4-Fluorobenzyl) piperazin-1-ylmethyl]pyrazolo [1,5-a]pyridine and Its in vitro Receptor Binding Assay" @default.
- W2356756803 hasPublicationYear "2013" @default.
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