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- W2356778640 abstract "Objective To investigate the pharmacodynamic function of different concentrations of suspension ofSan Teng(ST)on MRL/lpr lupus mice from thetime-effectandquantity-effect′views. Methods Traditional Chinese herbs of Tripterygium wilfordii Hook f,Sargentodoxa Cuneata(Oliv.)Rehd Et Wils and Spatholobus suberectus Dunn were extracted into different concentrations of ST suspension by a method of Ethanol extraction.Forty-eight 20-week-old female MRL/lpr lupus mice were randomly divided into six groups,including ST high dose group(K group,1.760g of crude drug/10g),ST moderate dose group(L group,0.880g of crude drug/10g),ST low dose group(M group,0.440g of crude drug/10g),anti-lupussangroup(Q group,0.022g pills/10g),prednisone control group(R group,prednisone 0.125mg/10g)and saline control MRL/lpr model group(S group,normal saline)with 8 weeks of continuous feeding.Each mouse was gavaged the capacity of 0.10mL per 10g weight body.Normal group was set with eight 8-week-old C57BL/6 female mice for normal saline control.Each 0.30mL of blood and 24 hours urine were collected on day 0,4 weeks and 8 weeks.The level of serum anti-ds-DNA antibody was detected by ELISA.The protein content of 24 hours urine was detected by method of Coomassie brilliant blue. Results After 4 and 8 weeks intervention of treatment,the body weight in K,L and M groups of mice was significantly lighter than that in R group(P0.05);The improvement of proteinuria in L,M and R groups was better than that in S group(P0.05),which showed that the effect of ST suspensions and prednisone could improve the proteinuria in MRL/lpr lupus mice;In improving the level of serum anti-ds-DNA antibody,it was significantly decreased in L,M,Q and R groups comparing with the model S group(P0.05)especially in L group;On renal pathological changes(total activity index,AI),the AI in K,L and M groups was similar to R group but better than that in group S. Conclusions ST capsule suspension can decrease the levels of serum anti-ds-DNA antibody,correct the proteinuria and ameliorate total activity index of renal pathological changes in MRL/lpr lupus mice.The efficacy was similar to the prednisone,especially in the dose of 0.880g of crude drug of ST/10g body weight without the hormone-like side effects of sodium and water retention,and shows a certaintime-effectandquantity-effectrelationship." @default.
- W2356778640 created "2016-06-24" @default.
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- W2356778640 date "2013-01-01" @default.
- W2356778640 modified "2023-09-26" @default.
- W2356778640 title "Pharmacodynamic study of San Teng(ST) extracted by a new method of ethanol extraction on MRL/lpr lupus mice" @default.
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