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- W2356797360 abstract "Objective The aim of this study is to investigate the effects of rapid pacing on atrial electrophysiological characteristics.Methods Acute atrial fibrillation was induced by rapid atrial pacing(S 1S 1)with a cycle length of 150 to 200 ms in 21 patients after successful radio frequency catheter ablation(RFCA).The effective refractory period(ERP),ERP dispersion and the inter-atrium/intra-atrium conduction time were measured with S 1S 2 scan(drive cycle length 400 ms)before and after rapid atrial pacing in multiple sites including high right atrium(HRA),low right atrium(LRA),HIS bundle area(HB)and right atrial appendage(RAA).To determine the ERP rate adaptating feature,ERPs were measured in RAA at 3 pacing cycle lengths(350,400,450 ms)respectively.Results As compared to parameters before rapid atrial pacing,atrial ERP shortened significantly in HRA[(193.2±25.5) ms vs(179.7±23.3) ms,[WTBX]P=0.001],LRA[(198.0±30.8) ms vs(182.0±22.5) ms,[WTBX]P=0.026],HB[(195.0±26.6) ms vs(182.0±16.8) ms,[WTBX]P=0.018] and RAA[(194.0±20.1) ms vs(180.0±29.0) ms,[WTBX]P=0.014] after rapid atrial pacing.Atrial ERPd after rapid pacing had no significant difference from that before rapid pacing[(25.0±17.8) ms vs(28.0±16.9) ms,[WTBX]P=0.576].ERPs of RAA also shortened after rapid pacing at various drive cycle length of{350 ms[(186.2±24.4) ms vs(168.7±30.9) ms,[WTBX]P=0.006],400 ms,400 ms[(194.0±20.1) ms vs(180.0±29.0) ms,[WTBX]P=0.014]and 450 msand 450 ms[(191.2±33.1) ms vs(170.0±28.3) ms,[WTBX]P=0.0001]}}.There is a strong correlation between ERPs and the pacing rates(r b=0.998,P=0.041)before rapid pacing,but there is no relationship between ERPs and pacing rates after rapid pacing(r a=0.397,P=0.74).The slope was almost normal(0.058)before rapid pacing,and lower(0.015) after rapid pacing.There is no significant difference in conduction time inter-atrium and intra-atrium,with a value of HRA-HB[(46.5±12.5) ms vs(48.4±12.0) ms,[WTBX]P=0.125]and HB-CSD[(47.0±14.2) ms vs(49.6±14.8) ms,[WTBX]P=0.153].Conclusion ERPs shorten obviously at different pacing cycle lengths and in different atrial sites,and atrial ERP adaptation to rates is poor after rapid pacing.But ERPd and conduction time inter-and intra-atrium remain unchanged after rapid pacing.These indicate atrial rapid pacing induces atrial electrophysiological remodeling,which plays an important role in developing,sustaining as well as progressing of atrial fibrillation." @default.
- W2356797360 created "2016-06-24" @default.
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- W2356797360 date "2001-01-01" @default.
- W2356797360 modified "2023-09-24" @default.
- W2356797360 title "The clinical study of atrial electrophysiological remodelling" @default.
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