Matches in SemOpenAlex for { <https://semopenalex.org/work/W2356819125> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2356819125 abstract "PurposeThe aim is to evaluate the effects of rhIL 11 made in China on hematopoietic recovery following chemotherapy induced thrombocytopenia in cynomolgus monkeys.MethodsChemotherapy induced myelosuppression of cynomolgus monkeys was made by china iv cyclophosphamide ( 30 mg/kg, qd ) for 5 days, then animals were divided 6 groups( n =4), by sc rhIL 11( 50, 100, 200 μg/kg), or Neumega (GI rhIL 11 control, 100 μg/kg) for 14 days, another normal control and model control. Blood was taken before chemothery and then at day 3, 6,9,12,15,18,21 for blood cell counts and platelet congregate test. Bone marrow was aspirated day 0, 12 and 21 for evaluation of the megakaryocyte ploidy distribution.ResultsRecovery of blood platelets was accelerated and reached normal levels by day 12, and was higher than normal day 18, day 21 sc rhIL 11 in cynomolgus moneys. Blood platelet congregated rate were 71.4%～74.6% by day 21 and higher than model control . megakaryocytes in bone marrow increased.ConclusionrhIL 11 could accelerate the recovery of peripheral blood platelets in monkeys. The function of increased platelets was normal. The results supported the clinical use of rhIL 11 as a platelet restorative agent to prevent severe thrombocytopenia following chemotherapy." @default.
- W2356819125 created "2016-06-24" @default.
- W2356819125 creator A5066560759 @default.
- W2356819125 date "2001-01-01" @default.
- W2356819125 modified "2023-09-25" @default.
- W2356819125 title "The effects of rhIL-11 on hematopoietic restoration following cyclophosphamide-induced thrombocytopenia in cynomolgus monkeys" @default.
- W2356819125 hasPublicationYear "2001" @default.
- W2356819125 type Work @default.
- W2356819125 sameAs 2356819125 @default.
- W2356819125 citedByCount "0" @default.
- W2356819125 crossrefType "journal-article" @default.
- W2356819125 hasAuthorship W2356819125A5066560759 @default.
- W2356819125 hasConcept C109159458 @default.
- W2356819125 hasConcept C126322002 @default.
- W2356819125 hasConcept C2776694085 @default.
- W2356819125 hasConcept C2776755627 @default.
- W2356819125 hasConcept C2779705218 @default.
- W2356819125 hasConcept C2779979121 @default.
- W2356819125 hasConcept C2780007613 @default.
- W2356819125 hasConcept C28328180 @default.
- W2356819125 hasConcept C54355233 @default.
- W2356819125 hasConcept C71924100 @default.
- W2356819125 hasConcept C86803240 @default.
- W2356819125 hasConcept C89560881 @default.
- W2356819125 hasConceptScore W2356819125C109159458 @default.
- W2356819125 hasConceptScore W2356819125C126322002 @default.
- W2356819125 hasConceptScore W2356819125C2776694085 @default.
- W2356819125 hasConceptScore W2356819125C2776755627 @default.
- W2356819125 hasConceptScore W2356819125C2779705218 @default.
- W2356819125 hasConceptScore W2356819125C2779979121 @default.
- W2356819125 hasConceptScore W2356819125C2780007613 @default.
- W2356819125 hasConceptScore W2356819125C28328180 @default.
- W2356819125 hasConceptScore W2356819125C54355233 @default.
- W2356819125 hasConceptScore W2356819125C71924100 @default.
- W2356819125 hasConceptScore W2356819125C86803240 @default.
- W2356819125 hasConceptScore W2356819125C89560881 @default.
- W2356819125 hasLocation W23568191251 @default.
- W2356819125 hasOpenAccess W2356819125 @default.
- W2356819125 hasPrimaryLocation W23568191251 @default.
- W2356819125 hasRelatedWork W118701769 @default.
- W2356819125 hasRelatedWork W1963830170 @default.
- W2356819125 hasRelatedWork W1975548484 @default.
- W2356819125 hasRelatedWork W1999067208 @default.
- W2356819125 hasRelatedWork W2085405541 @default.
- W2356819125 hasRelatedWork W2343381302 @default.
- W2356819125 hasRelatedWork W2347214568 @default.
- W2356819125 hasRelatedWork W2356505737 @default.
- W2356819125 hasRelatedWork W2371193663 @default.
- W2356819125 hasRelatedWork W2373002801 @default.
- W2356819125 hasRelatedWork W2376108772 @default.
- W2356819125 hasRelatedWork W2383591769 @default.
- W2356819125 hasRelatedWork W2395042169 @default.
- W2356819125 hasRelatedWork W2410140063 @default.
- W2356819125 hasRelatedWork W2415003089 @default.
- W2356819125 hasRelatedWork W2416876205 @default.
- W2356819125 hasRelatedWork W2418425957 @default.
- W2356819125 hasRelatedWork W2438448275 @default.
- W2356819125 hasRelatedWork W2474495339 @default.
- W2356819125 hasRelatedWork W3032314161 @default.
- W2356819125 isParatext "false" @default.
- W2356819125 isRetracted "false" @default.
- W2356819125 magId "2356819125" @default.
- W2356819125 workType "article" @default.