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- W2356844079 abstract "Purpose To investigate the molecular mechanism of parathyroid hormone (PTH) enhancing bone formation at the level of bone marrow microenvironment. Methods Twenty monthold 8 rats divided into 2 groups were randomly assigned to receive either subcutaneous doses of recombinant human parathyroid hormone (rhPTH) or normal saline (NS),5 times/week.After 8 weeks,bone marrow cells (BMC) were collected from femur and lumbar vertebra.Semi-quantity RT-PCR was used to analysed the mRNA expression of alkaline phosphatase (ALP),bone Gla-containing protein (BGP),core binding factor alpha 1 (Cbfα1) which relates to bone forming,receptor activator of NF-κB ligand (RANKL),osteoprotegerin(OPG),macrophage colony stimulating factor(M-CSF)、tumor necrosis factor receptor-associated factor 6 (TRAF6) and interleukin(IL-6) which relates to osteoclast differentiation and maturation. Results PTH significantly increased mRNA expression of Cbfα1、ALP and BGP that relates to bone forming in BMC(P0.05- 0.001);PTH regulated mRNA expression of genes relates to osteoclast differentiation and maturation:RANKL、M-CSF and TRAF6 mRNA were down-regulated in PTH group(P0.05-0.01),OPG and IL-6 mRNA were up-regulated (P0.01 and P0.05 respectively).Similar changes of mRNA expression of the above genes existed both in femur BMC and in lumbar vertebra BMC. Conclusions PTH increasing old rats' bone mass may be related to its dramatically enhancing the expression of genes related to bone for-ming as well as regulating the expression of genes related to osteoclast differentiation and maturation in bone marrow microenvironment." @default.
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- W2356844079 date "2005-01-01" @default.
- W2356844079 modified "2023-09-26" @default.
- W2356844079 title "Method of parathyroid hormone acting on bone metabolism--related genes expression of old rats' bone marrow cells" @default.
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