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- W2356857752 abstract "Objective:To further investigate the influence of proton pump inhibitors,such as Pantoprazole and Rabeprazole,on clopidogrel antiplatelet effects.Methods:154 cases with acute coronary syndrome and percutaneous coronary intervention were selected,and had checked by cardiovascular physician in Inner Mongolia autonomous region people's hospital form December 2009 to March 2011.All patients were randomly divided into three groups.The experimental group 1(62cases) were given clopidogrel 75 mg·d-1and pantoprazole 80 mg·d-1;The experimental group 2(41cases) were given clopidogrel 75 mg·d-1 and rabeprazole 10 mg·d-1;The control group(51 cases) were given only clopidogrel 75 mg·d-1.All patients recieved a clopidogrel loading doses 300 mg at the start of clopidogrel treatment,and then given clopidogrel 75 mg·d-1 and Aspirin300 mg·d-1 for seven to ten days by continuous.The Flow Cytometric was used to analysis platelet P-selectin positive rate(%),before treatment and the seventh day after taking medicine and then statistical analysis was performed.Results:Before and after the treatment,the platelet P-selectin positive rate(%) of the control group was 10.34±6.84 and 5.24±6.40 respectively(P0.05);the platelet P-selectin positive rate of the experimental group 1 was 9.14±4.82 and 4.03±2.72 respectively(P0.05);the platelet P-selectin positive rate of the experimental group 2 was 9.16±4.92 and 6.41±2.83 respectively(P0.05).Camparing between every two groups,there was no the difference(P0.05).Conclusions:①There is no significance between patients taking clopidogrel plus PPI and clopidogrel without PPI.②The thrapeutic doses of Pantoprazole and Rabeprazole has no effect on Clopidogrel of antiplatelet curative effect in short period." @default.
- W2356857752 created "2016-06-24" @default.
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- W2356857752 date "2012-01-01" @default.
- W2356857752 modified "2023-09-25" @default.
- W2356857752 title "The Evaluation of the Influence of Proton Pump Inhibitors on Clopidogrel Antiplatelet Effects" @default.
- W2356857752 hasPublicationYear "2012" @default.
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