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- W2356867041 abstract "OBJECTIVE To investigate molecular epidemiology on aminoglycoside modifying enzyme gene of Pseudomonas aeruginosa. METHODS PCR method was used to detect and analyzed P. aeruginosa aminoglycosides resistance associated genes, aminoglycosides modifying enzyme genes aac(3) Ⅰtype,aac(3) Ⅱtype, aac(3) Ⅲ type, aac(3) Ⅳ type, aac(6′) Ⅰ type, aac(6′) Ⅱ type, aph(3′) Ⅵ type, ant(3″) Ⅰtype and ant(2″) Ⅰtype in 35 P. aeruginosa strains. RESULTS Aminoglycosides modifying enzyme genes were detected in 20 of all 35 P. aeruginosa strains (57 1%). The detected rate of the nine types of genes was ordered as aac(6′) Ⅱ(34 2%), ant(2″) Ⅰ(28 6%), aac(3) Ⅱ(17 1%), aac(6′) Ⅰ(17 1%), ant(3″) Ⅰ(14 3%), aac(3) Ⅰ(0), aac(3) Ⅲ(0), aac(3) Ⅳ(0), and aph(3′) Ⅵ(0). CONCLUSIONS The study indicated that in Xiangfan area, Hubei Province the essential mechanisms of aminoglycoside resistance in P. aeruginosa result in producing aminoglycosides modifying enzyme (57 1%).In addition, in this group 15 strains are resistant to aminoglycosides but the nine types of genes are negative, the other modifying enzyme gene is possible or 16S rRNA mutation occurred." @default.
- W2356867041 created "2016-06-24" @default.
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- W2356867041 date "2005-01-01" @default.
- W2356867041 modified "2023-09-25" @default.
- W2356867041 title "Aminoglycosides Modifying Enzyme Gene of Pseudomonas aeruginosa: A Molecular Epidemiology Study" @default.
- W2356867041 hasPublicationYear "2005" @default.
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