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- W2356875512 abstract "Aim To study the effect of 2,3,4′,5-tetrahydroxystilbene-2-O-β-D glucoside(TSG) on vascular smooth muscle cells(VSMCs) proliferation induced by fetal bovine serum and explore the underlying mechanisms.Methods VSMCs were cultured from rat aorta using explant technique.VSMCs proliferation was analyzed by 5-bromo-2-deoxyuridine(Brdu) incorporation assay.Cell cycle phase distributions were determined by flow cytometry.The expression of proliferating cell nuclear antigen(PCNA) was evaluated by Western blot analysis.The level of intracellular reactive oxygen species(ROS) was estimated through fluorescence assay.The intracellular activities of superoxide dismutase(SOD),catalase(CAT),and glutathi one peroxidase(GSH-px) were measured using biochemical method.Results TSG in the experimental concentration 0.1～100 μmol·L~-1 exhibited no apparent cytotoxocity.10 μmol·L~-1 and 100 μmol·L~-1 TSG significantly inhibited the proliferation of VSMCs induced by serum,cell cycle transition from G0/G1phase to S phase,PCNA expression in nucleus of VSMCs and level of intracellular ROS.100 μmol·L~-1 TSG markedly increased the activities of SOD and GSH-px.Conclusions Certain concentration of TSG can prevent VSMCs proliferation effect mediated by serum;the mechanism about TSG effect may be associated with arresting G0/G1 to S progression,decreasing PCNA expression and improving the antioxidation of VSMCs." @default.
- W2356875512 created "2016-06-24" @default.
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- W2356875512 date "2010-01-01" @default.
- W2356875512 modified "2023-09-24" @default.
- W2356875512 title "Effect of 2,3,4′,5-tetrahydroxystilbene-2-O-β-D glucoside on proliferation and antioxidation of vascular smooth muscle cells" @default.
- W2356875512 hasPublicationYear "2010" @default.
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