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- W2356877811 abstract "Objective To observe the change in gastric mucosa of the rats with acute cerebral infarction and study the protective effect of tongqiao huoxue decoction on gastric tissue in cerebral infarction at the acute stage. Methods The intraluminal middle cerebral artery occlusion with thread bolt method was used to prepare focal cerebral ischemia rat model. All of the rats were divided into a normal control group,a sham- operation group,a cerebral infarction group,a cimetidine group,a regular dose group and a low dose group of tongqiao huoxue decoction. The corresponding drugs were applied with gastric infusion in each group. Gastric infusion was given continuously,once a day and the rats were sacrificed in 4 days. The gastric tissue was separated and GAS was observed under electric microscope. Results In the cerebral infarction group,GAS was apparently higher than the other groups( P 0. 01),GAS in the regular dose group of tongqiao huoxue decoction was lower than that in the low dose group( P 0. 01) and that was lower much apparently than that in the cimetidine group( P 0. 01). Compared with the normal control group and the sham- operation group,the structure of gastric mucosa was destroyed apparently. The destroyed tissue was alleviated in the regular dose group and the low dose group of tongqiao huoxue decoction,as well as the cimetidine group. The efficacy in the regular dose group was better than that in the cimetidine group. Conclusion Gastric mucosa in cerebral infarction at the acute stage is damaged apparently,which is closely related to the increasing of GAS. Tongqiao huoxue decoction protects gastric mucosa in acute cerebral infarction and the efficacy is relevant with the dose." @default.
- W2356877811 created "2016-06-24" @default.
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- W2356877811 date "2015-01-01" @default.
- W2356877811 modified "2023-09-25" @default.
- W2356877811 title "Protective Effect of Tongqiao Huoxue Decoction on Gastric Mucosa in Acute Cerebral Infarction" @default.
- W2356877811 hasPublicationYear "2015" @default.
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