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- W2356895839 abstract "OBJECTIVE:To observe clinical effects of Salvia miltiorrhiza ligustrazine injection combined with large-dose Astragalus membranaceus injection on diabetic nephropathy(DN).METHODS:80 DN patients were randomly divided into treatment group and control group.Except conventional western medicine treatment,S.miltiorrhiza ligustrazine injection 10 ml combined with 0.9% Sodium chloride injection 250 ml was used in treatment group,and A.membranaceus injection 60 ml added into 0.9% Sodium chloride injection 200-400 ml was used intravenously with the amount of A.membranaceus injection increasing to 120 ml within 3-5 d.Control group only received S.miltiorrhiza ligustrazine injection 10 ml combined with 0.9% Sodium chloride injection 250 ml intravenously.The treatment course for both groups was 21 d.Changes of blood rheology,renal function and clinical symptoms and signs were observed in 2 groups before and after treatment,while ADR monitoring was carried out simultaneously.RESULTS:There was statistical significance in the improvement of blood rheology index between 2 groups before and after treatment(P0.05),and there was no statistical significance in blood rheology index between 2 groups after treatment(P0.05).There was statistical significance in the improvement of renal function between 2 groups before and after treatment(P0.05).Compared with control group,24 h UPQ,BUN and Scr of treatment group decreased significantly,there was statistical significance between 2 groups(P0.05);bloated face and limb edema,cold extremities,ache and weak at waist and knee,fatigue and other clinical manifestations were improved significantly in treatment group after treatment,compared with control group.No obvious ADR was found in 2 groups.CONCLUSIONS:S.miltiorrhiza ligustrazine injection combined with high-dose A.membranaceus injection can significantly reduce the albuminuria and improve the renal function and clinical symptoms in DN patients with sound safety." @default.
- W2356895839 created "2016-06-24" @default.
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- W2356895839 date "2013-01-01" @default.
- W2356895839 modified "2023-09-28" @default.
- W2356895839 title "Clinical Observation of Salvia Miltiorrhiza Ligustrazine Injection Combined with Large-dose Astragalus Membranaceus Injection for Diabetic Nephropathy" @default.
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