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- W2356907990 abstract "Objective To explore the mechanisms of inhibition of artemether (Artm) on glioma growth in brain tumor bearing SD rat.Methods MTT (Methy thiazolyl tetrazolium) assay was used to evaluate the inhibitory effect of artemether treatment on C6 glioma cells. Forty-eight (24 male and 24 female) SD rats which were subcutaneous planted with SD rat C6 glioma cell to establish SD rat orthotopic glioma model were divided resourcefully into 6 groups. They were control group; model groups, artemether 33.3 mg/(kg·d), 50 mg/(kg·d), 66.6 mg/(kg·d); two drugs combined group, artm 50 mg/(kg·d)+ ferrous sulfate 1.5 mg/(kg·d) and positive control group. Lomustine 20 mg/(kg·d) SD rats of each group were fed for 10 consecutive days. Inhibitive rates of Artemether were calculated by a2bπ∕6.Results Artemether could inhibit the proliferation of C6 glioma cells in concentration and time -depended manners. Inhibitive rates of artemether in different dosages were 54.5%、61.0%、64.5% and 69.8% respectively. Compared among model groups, inhibitive rates of artemether 66.6 mg/(kg·d) was higher than that of artemether 33.3 mg/(kg·d), there was a significant difference between two group (P0.05). Compared among experiment groups, inhibitive rate of Artm + ferrous sulfate was higher than that of 33.3 mg/(kg·d), there was a significant difference (P0.05).Conclusion Artemether can inhibit glioma growth in SD rat orthotopic glioma model." @default.
- W2356907990 created "2016-06-24" @default.
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- W2356907990 date "2010-01-01" @default.
- W2356907990 modified "2023-09-24" @default.
- W2356907990 title "Inhibitive Effect of Artemether on Glioma Growth in SD Rat Orthotopic Glioma Model" @default.
- W2356907990 hasPublicationYear "2010" @default.
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