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- W2356913578 abstract "Objective Study the protective effect of Calcium Antagonist Nifedipine,on myocardial ischemia-reperfusion injury in isolated rat hearts.Methods Rat myocardial ischemia-reperfusion injury model was established by consisting of a 30 min(reducing perfusion flow level of left and right coronary to 5% of the original irrigation flow) ischemic period and 2h reperfusion,the isolated rat hearts were perfused on modified Langendorff apparatus.The rats were divided into control group,ischemia/reperfusion(I/R) group,Nifedipine group,then detected the myocardial infarct area,the levels of SOD and MDA,and PKCδ were detected by immunoHistochemistry,Semi-quantitative RT-PCR was employed to measure the mRNA levels of NCX and SERCA2a.Results(1) Compared with the I/R group,the myocardial infarct area was significantly lower,(2) SOD activity increased significantly and MDA decreased significantly;(3) Nifedipine group,compared with model group,levels of PKC increased(P0.05);(4)expression of NCX mRNA in Nifedipine group was lower than the model group,there were significant differences(P0.05);expression of SERCA2α mRNA in Nifedipine group was significantly increased compared with the model group(P0.05).Conclusion The calcium antagonist Nifedipine on myocardial ischemia-reperfusion injury has a protective effect." @default.
- W2356913578 created "2016-06-24" @default.
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- W2356913578 date "2012-01-01" @default.
- W2356913578 modified "2023-09-23" @default.
- W2356913578 title "Protective Effect of Calcium Antagonist Nifedipine on Myocardial Ischemia-reperfusion Injury in Isolated Rat Hearts" @default.
- W2356913578 hasPublicationYear "2012" @default.
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