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- W2356936610 abstract "AIM: To investigate the effect of gamma-ray irradiation on β-amyloid peptide-induced damage of erythrocyte membranes.METHODS: Erythrocytes were irradiated with gamma-ray(50 and 100 Gy) before treated with β-amyloid peptide(Aβ).Hemolysis rate,osmotic fragility,morphology and membrane fluidity of erythrocyte were determined by means of spectroscopy,scan electron microscopy and fluorescent probe,respectively.RESULTS: Gamma-ray irradiation inhibited erythrocyte hemolysis in a dose-dependent manner,although only the 100-Gy irradiation had decreased the rates of Aβ-induced and spontaneous hemolysis from(3.76±0.50)% and(11.90±1.50)% to(1.87±0.09)% and(7.90±0.90)%,respectively,showing significant inhibition(P0.05).Treatment of erythrocytes with both gamma-ray doses decreased morphological alteration and anisotropy values of the probe in membrane of the cells in the presence of Aβ(P0.05),from 0.36±0.01 to 0.33±0.00 and 0.32±0.01,respectively.The osmotic fragility of erythrocytes,expressed as the NaCl concentrations of the buffer that corresponding to 50% cell lysis,decreased from 82.3 mmol/L(control) to 80.7 mmol/L(50 Gy) and 76.9 mmol/L(100 Gy),respectively.CONCLUSION: Gamma-ray irradiation protected erythrocyte membranes from damages induced by β-amyloid peptide.This can be attributed to that gamma irradiation increases membrane fluidity and stability of the cells." @default.
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- W2356936610 date "2008-01-01" @default.
- W2356936610 modified "2023-09-24" @default.
- W2356936610 title "Effect of gamma ray irradiation on β-amyloid peptide-induced damage of erythrocyte membrane" @default.
- W2356936610 hasPublicationYear "2008" @default.
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