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- W2356939936 abstract "AIM To explore the role of serum CD40L and matrix metalloproteinses(MMPs) levels in coronary plague formation. METHODSFiftynine (31 men and 28 women, mean age 603 years) acute coronary syndrome patients with coronary stenosis confirmed by coronary arteriography were divided into acute myocardial infarction (AMI) group (n=27) and unstable angina pectoris (UAP) group (n=32), and a normal control group (n=30) was set up. The levels of serum CD40L, MMP-2 and MMP-9 were detected by ELISA. RESULTSCompared with those in normal control group, the levels of serum CD40L, MMP-2 and MMP-9 were significantly elevated along with exacerbation of the disease (P0.01) and the levels of serum CD40L, MMP-2 and MMP-9 in the patients with multiple coronary lesions were higher than those in the patients with single coronary lesion. The levels of serum CD40L, MMP-2 and MMP-9 were positively correlated with that of CD40L (r=0.71 and 0.78, respectively). CONCLUSIONThe elevation of serum CD40L, MMP-2 and MMP-9 levels are to some extent related to the coronary plague formation. CD40L may cause coronary lesion by way of MMPs, thus leading to the coronary plague formation and the development of coronary diseases." @default.
- W2356939936 created "2016-06-24" @default.
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- W2356939936 date "2009-01-01" @default.
- W2356939936 modified "2023-09-27" @default.
- W2356939936 title "Role of CD40L and matrix metalloproteinses in pathogenesis of acute coronary syndrome" @default.
- W2356939936 hasPublicationYear "2009" @default.
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