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- W2356944224 abstract "The sulforhodamine B(SRB) assay was employed to evaluate the anti-tumor effect of petroleum ether extracts from Fomitopsis officinalis(Vill.:Fr.) Bond(PEFO) on SMCC-7721,SGC-7901,and Hep-2 cell lines in vitro.The results showed PEFO inhibited the growth of three kinds of cells in dose-dependent manner with the IC50values on SMCC-7721,SGC-7901,and Hep-2 cells being of 58.74,74.13 and 83.18 μg/mL,respectively.The SMCC-7721 cells exposed to PEFO obviously changed cell morphology and cellular ultrastructure.The SMCC-7721 cell presented wrinkled nuclei,poor cell adherent growth and cell lysis,while mitochondria swell and a large number of vacuoles in cytoplasm were observed by transmission electron microscope.The flow cytometry results revealed that SMCC-7721cell decreased in S-phase and increased in G0/G1-phase,which arrested in G0/G1 phase.The study demonstrated that PEFO could inhibit cell proliferation in vitro,and the anti-tumor activity of PEPO might be achieved by inhibition of tumor cellular aerobic metabolism and intervention cell cycle." @default.
- W2356944224 created "2016-06-24" @default.
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- W2356944224 date "2013-01-01" @default.
- W2356944224 modified "2023-09-24" @default.
- W2356944224 title "Effect of Petroleum Eether Extracts from Fomitopsis officinalis (Vill.:Fr.) Bond. on Tumor Cell Proliferation and Cell Cycle" @default.
- W2356944224 hasPublicationYear "2013" @default.
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