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- W2356956956 abstract "Objective:To probe into the prophylactico-t he rapeutic effect of leizhusun juice (LZS) on the experimental liver injury in rats. Methods:44 wistar rats were randomly divided into four g roups. 8 animals of group 1 served as blank controls. Rats of group 2,3 and 4(wi th 12 animals in each group) were given each by gastrogavage normal saline, 205. 70 mg·kg -1 of LZS and 436.40 mg·kg -1 of LZS in equal volumes res pectively, q.d. for 7 consecutive days. After the last medication, each animal o f group 2,3 and 4 was given an intraperitoneal injection of 0.1 mL/100 g body we ight of 50% CC1 4 in peanut oil. 72 hours later blood was taken from each of th e 8 surviving animals of the four groups and serum separated for the determinati on of the activities of alanine aminotranferase (ALT), aspartate aminotranferase (AST) and superoxide dismutase (SOD) as well as the content of malonyldialdelyd e (MDA). Results:CC1 4 was shown to cause a sharp rise in the se rum levels of ALT, AST and MDA and a striking fall of the serum SOD level in ani mals of group 2. In rodents of group 3 and group 4 that had been pretreated with two different doses of LZS before CC1 4 poisoning the serum levels of ALT, AST and SOD were significantly lower while the serum content of MDA was significant ly higher than those of the animals of group 2 (P0.05,P0.01). A dose -effect relationship of LZS was also demonstrated. Conclusion:LZS was shown to have a distinct prophylsctic o-therapeutic effect directed against acute liver injury induce by CC1 4 in ra ts, the underlying mechanism maybe related to its effect of antioxidation." @default.
- W2356956956 created "2016-06-24" @default.
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- W2356956956 date "2004-01-01" @default.
- W2356956956 modified "2023-09-23" @default.
- W2356956956 title "The Prophylactico-therapeutic Effect of Leizhusun Juice on the Liver Injury Induced by Carbon Tetrachloride in Rats" @default.
- W2356956956 hasPublicationYear "2004" @default.
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