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- W2357004228 abstract "Objective:To investigate the inhibitory effect of attenuated salmonella typhimurium vaccine,which expressing xenogeneic chicken EGFR and IgG γFc,on the growth of Lewis lung cancer(expressed high level of EGFR)-implanted tumors in mice.Methods: pVAX1/ cEGFR-γFc plasmid was transformed into attenuated salmonella typhimurium strain SL7207,and the resultant SL7207/pVAX1-cEGFR-γFc bacteria were used to infect murine peripheral macrophage in vitro.Then expression of cEGFR-γFc fusion protein was detected by immunofluorescent assay.Mice were immunized with SL7207/pVAX1-cEGFR-γFc for 3 times,and then inoculated with Lewis cells.Expression of cEGFR-γFc fusion protein in mice tissue was detected by Western blotting analysis,and serum anti-EGFR level was determined by ELISA method.The weight of implanted Lewis tumor was measured after 14 d to investigate the anti-tumor effect of SL7207/pVAX1-cEGFR-γFc vaccine,and the survival time of tumor-bearing mice was also examined.Results: The attenuated salmonella typhimurium DNA vaccine SL7207/pVAX1-cEGFR-γFc was successfully constructed.The cEGFR-γFc fusion protein could be expressed in mouse cells after SL7207/pVAX1-cEGFR-γFc infection in vitro and in vivo.The mice immunized with SL7207/pVAX1-cEGFR-γFc could produce high level of anti-EGFR antibody.The tumor growth was obviously inhibited and the survival time of tumor-bearing mice was also increased in the SL7207/pVAX1-cEGFR-γFc vaccine group.Conclusion: The DNA vaccine expressing xenogeneic EGFR can effectively inhibit the growth of EGFR-positive tumors,which is a new EGFR-targeting therapy strategy." @default.
- W2357004228 created "2016-06-24" @default.
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- W2357004228 date "2010-01-01" @default.
- W2357004228 modified "2023-09-28" @default.
- W2357004228 title "Oral DNA vaccine expressing xenogeneic EGFR inhibits growth of Lewis lung cancer in mice" @default.
- W2357004228 hasPublicationYear "2010" @default.
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