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- W2357016737 abstract "Objective To evaluate the applicability of X-specific short tandem repeats (X-STRs) in identification of fetal cells, the fetal sex and the common sex chromosome aneuploidy in noninvasive prenatal diagnosis. Methods Thirty-three peripheral blood samples were obtained from pregnant women. Fetal nucleated erythrocytes were discerned with heamoglobin γ chain staining and separated under microscopy. After primer extension preamplification (PEP), two X-STRs (DXS101, DXS6797) and AMXY gene were amplificated. Fetal sex was judged by comparing the genotype of fetus with that of its parents. Results Fetal nucleated red blood cells were separated from all samples. In each case, fetal sex was accurately diagnosed by analyzing DXS101, DXS6797 and AMXY gene, with a coincidence rate of 100%. A fetus with Turner′s syndrome was also diagnosed with this noninvasive technique successfully. Conclusion Amplification of X-STRs and AMXY gene can accurately detect fetal sex and common sex chromosome aneuploidy. This procedure is rapid and cheap, and can be used for discerning both male fetus and female fetus with a wide perspective of development." @default.
- W2357016737 created "2016-06-24" @default.
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- W2357016737 date "2006-01-01" @default.
- W2357016737 modified "2023-09-27" @default.
- W2357016737 title "Noninvasive prenatal diagnosis of fetal sex and common sex aneuploidy with short tandem repeats" @default.
- W2357016737 hasPublicationYear "2006" @default.
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