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- W2357018112 abstract "Objective: In order to investigate the relationship between hepatocyte growth factor/scatter factor(HGF/SF),nitric oxide(NO),transforming growth factor-β 1(TGF-β 1)and atheriosclerosis obliterans(ASO).Methods: 60 cases of ASO were divided into three groups according to the severity:the intermittent claudation group(30 cases),the rest pain group(18 cases)and gangrene group(12 cases).HGF/SF,TGF-β 1,NO and Ankle-Brachial index(ABI)were determined in the patients and normal controls(30 cases)respectively.Results: HGF/SF and NO in the patients were significantly lower in ASO than in normal controls(P0 01,P0 05)and the levels were significantly decreaesd with the severity increased,but the TGF-β 1 on the contrary.There was a powerful negative correlation between HGF/SF and TGF-β 1 (γ=-0 6612,P0 01).ASO with diabetes had a lower HGF/SF,NO and ABI but a higher TGF-β 1.The follow-up showed bad results with lower HGF/SF.Conclusion: HGF/SF and TGF-β 1 might play an important role in the pathogenesis of ASO,and can be a good reference for judging the severity and early diagnosis parameter of ASO." @default.
- W2357018112 created "2016-06-24" @default.
- W2357018112 creator A5091666919 @default.
- W2357018112 date "2001-01-01" @default.
- W2357018112 modified "2023-09-23" @default.
- W2357018112 title "The significance of HGF/SF,TGF-β_1 and NO in the pathogennesis of atheriosclerosis obliterans" @default.
- W2357018112 hasPublicationYear "2001" @default.
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