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- W2357029010 abstract "Objective:To observe the effect of CDK inhibitor-olmoucine on cultured astrocyte proliferation after mechanical and to explore the mechanism.Methods:The model of mechanical on cultured purified astrocytes was established.The cultured cells were randomly divided into 3 equal groups:control group,scratch group(scratch + vehicle),and olomoucine group(scratch + olomoucine).Immunofluorescence(IF)staining was used to detect the expression of glial fibriliary acidic protein(GFAP)and BrdU.Western bolt was used to detect the expression of PCNA and p27.Results:The scratch-wound injury can induce AS proliferation.From 12 hours after injury,AS around the area appeared hypertrophic and proliferative.The percent of the BrdU-positive cells and the expression of PCNA increased(P0.05),while the expression of p27 decreased(P0.05).In the olomoucine group,the percent of the BrdU-positive cells and the expression of PCNA were be inhibited significantly by olomoucine(P0.05).Conclusion:As a response of injury,AS entered cell cycle and appeared reactive gliosis.The cell cycle inhibitor,olomoucine can inhibit injury-induced reactive gliosis by regulating cell cycle." @default.
- W2357029010 created "2016-06-24" @default.
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- W2357029010 date "2008-01-01" @default.
- W2357029010 modified "2023-09-23" @default.
- W2357029010 title "The Effect of Olomoucine on Cultured Astrocyte Proliferation and its Mechanism Research" @default.
- W2357029010 hasPublicationYear "2008" @default.
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