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- W2357031713 abstract "Objective To investigate the relationgship between the promoter hypermethylation of O6-methylguanine DNA methyltransferase (MGMT) gene and expression of K-ras in non-small-cell lung cancer(NSCLC).Methods Methylation specific PCR (MSP) and immunohistochemical methods were used to detected methylation status of MGMT gene and K-ras expression in 98 patients with NSCLC.Results The rate of the promoter hypermethylation of MGMT gene in 98 NSCLC was 31.6%(31/98),the rate of expression of K-ras was 46.9%(46/98).The MGMT gene promoter methylation rate and K-ras protein expression rate in the control group of 10 normal lung tissue both was 0(0/98).The promoter hypermethylation rate of MGMT gene and the expression of K-ras in NSCLC patients with the stage Ⅲ of P-TNM,lymph node metastasis and smoking patients,was higher than that in patients with stage Ⅰ～Ⅱ,no lymph node metastasis and without smoking.(all P0.05).There was positive correlation between the promoter hypermethylation of MGMT and the expression of K-ras in NSCLC(Rs=0.591,P0.05).Conclusion The promoter hypermethylation of MGMT gene may lead to the activation of K-ras gene.They may take part in NSCLC evolvement." @default.
- W2357031713 created "2016-06-24" @default.
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- W2357031713 date "2010-01-01" @default.
- W2357031713 modified "2023-09-26" @default.
- W2357031713 title "Promoter Hypermethylation of MGMT Gene and Expression of K-ras in Human Non-small-cell Lung Cancer" @default.
- W2357031713 hasPublicationYear "2010" @default.
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