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- W2357034457 abstract "Objective:To investigate the protective effect of lovastatin on the ischemic and reperfused rat myocardium and its mechanism. Method:Twenty-four Sprague-Dawley male rats were randomly and evenly divided into three groups: model control group; Lovastatin group treated with 15 mg lovastatin per a kilogram once a day; L-NAME group treated with the same dose of lovastatin with lovastatin group and L-NAME 30 mg per a kilogram once a day. Rat models of I/R were established with coronary occlusion 30 mintues and reperfusion 30 mintues of the left anterior descending artery after two-week's administration. Hemodynamics was monitored during the period of ischemia and reperfusion. Superoside dismutase of myocardial tissue and malondialdehyde in blood serum were measured as well as lipin in blood serum. Result: In comparison with model control group, heart rate was reduced markedly and reperfused arrhythmia disappeared in the L group and N group.The descent of -dp/dt in the reperfused period was improved in both L and N group. Without lipin in the blood serum changed, Lovastatin decreased the yield of malondialdehyde(MDA) in the blood serum and rise the activity of superoside dismutase (SOD)in the myocardial tissue after ischemia and reperfusion.Conclusion: Lovastatin may have the protective effect on the ischemic and reperfused rat myocardium,but such effects didn't correclate to its effect on lipin in blood serum.There may have another something or pathway which correclate to its effect as well as NO synthesis increasing." @default.
- W2357034457 created "2016-06-24" @default.
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- W2357034457 date "2005-01-01" @default.
- W2357034457 modified "2023-09-25" @default.
- W2357034457 title "The study of myocardial protection and its mechanisms of lovastatin preconditioning in the ischemic and reperfused rat hearts" @default.
- W2357034457 hasPublicationYear "2005" @default.
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