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- W2357040436 abstract "The cell culture character, safety, efficacy and antibody duration of gene-deleted Pseudorabies virus vaccine strain (SA215), which lacked gE, gI and thymidine kinase (TK) genes, but can express LacZ gene were tested in this study. SA215 could adapt to Vero cells and induce plaqueu formation. It was safe to 1-day-old piglets, pregnant sows, cattle, sheep, goats and rabbits, moreover, the animals vaccinated with SA215 strain were less clinically affected and the SA215 strain virus couldn’t be recovered from vaccinated animals. Inoculation of SA215 could protected pigs from challenge of Fa strain, the virulent Pseudorabies virus, at a dose of 10~(7) PFU. The periods of fever and growth arrest and titer of excreting virus of the pigs vaccinated with SA215 were lower than those of the pigs vaccinated with Bartha strain, but were much lower than that of the unvaccinated pigs. The vaccinated pigs with SA215 strain produced high-level anti-PRV neutralizing antibodies that could provide protection from infection till 16 weeks after vaccination. The results showed that SA215 strain was a safe vaccine that had good immunogenicity." @default.
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- W2357040436 date "2005-01-01" @default.
- W2357040436 modified "2023-09-25" @default.
- W2357040436 title "The Biological Characteristics of a Gene-deleted Pseudorabies Virus Vaccine Strain (SA215)" @default.
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